Histiocytes


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Histiocytes

 

(wandering cells at rest; polyblasts; clasmatocytes), cells of reticular connective tissue in vertebrate animals and humans. Histiocytes are sharply contoured, with basophilic cytoplasm, in which there are often vacuoles and inclusions. The shape of the cell varies owing to its capacity for amoeboid movement. Histiocytes perform a protective function by trapping and digesting various foreign particles, including bacteria. In various types of irritations—for example, in inflammatory reactions—the histiocytes are activated and transformed into typical macrophages. Sometimes the cytoplasm of histiocytes forms short, rounded projections that break away from the body of the cell (clasmatosis). In embryos, histiocytes develop from the mesenchyme, and in the adult body they develop from undifferentiated cells of reticular connective tissue, reticular tissue, and certain kinds of blood cells—lymphocytes and monocytes.

E. S. KIRPICHNIKOVA

References in periodicals archive ?
In our patient, the lymph node demonstrated paracortical necrosis, histiocytes, immunoblasts, and an absence of neutrophils and plasma cells--findings consistent with Kikuchi-Fujimoto disease.
Originally described by Juan Rosai and Ronald Dorfman in 1969, (1) RDD was observed as a triad of massive cervical lymphadenopathy, expanded lymph node sinuses, and characteristic emperipolesis within histiocytes.
Foamy histiocytes may also present extensively in papillary RCC.
Histopathology results show an abundance of histiocytes with grooved nuclei intermingled with large numbers of eosinophils.
Recent cytologic studies, of small series, have emphasized the usefulness of neoplastic epithelial cells, reactive mesothelial cells, acellular mucin, histiocytes and spindle cells in making the diagnosis of PMP (7,8,9).
23) In the tissue, leishmaniasis is characterized by a subepithelial nonnecrotizing granulomatous inflammatory reaction with lymphocytes, plasma cells, and histiocytes as the predominant cells.
We found numerous acid-fast bacilli within histiocytes and invading nerves (Figure 2), highlighted by Fite, Gomori methenamine silver, and Gram stains; Ziehl-Neelsen stain highlighted only a few organisms.
Histology showed several voluminous eosinophilic intranuclear inclusions of probable viral nature in endothelial cells, histiocytes in lung parenchyma (Fig.
Histiocytes containing laminated calcified spherules, commonly known as Michaelis-Gutmann (MG) bodies, were also seen (fig-1).
Definite diagnosis can be made by CD68(+) CD1a(-) histiocytes seen in biopsy specimen.
The histology report showed a benign, non-neoplastic lesion characterised by expanded sinuses that were filled with enlarged histiocytes containing abundant cytoplasm and plasma cells.
BAL fluid analysis showed total cell count 320/cmm, histiocytes 72%, alveolar macrophages 22%, lymphocytes 2%, and neutrophils 4%.