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A science that deals with the distribution and activities of chemical components in tissues.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



the division of histology that studies the chemical properties of animal and plant tissue.

Histochemistry seeks to elucidate the characteristics of metabolism in tissue cells and interstitial media. It studies changes in cell properties in the process of development and the connection between the work, metabolism, and renewal of mature cells and tissues. A basic principle of histochemical methodology is the bonding of a definite chemical component of cells with a stain or the formation of a stain in the process of the reaction. A number of methods (cytophotometry and luminescence and interference microscopy) are based on the physical properties of substances. Various histochemical methods determine the localization and quantity of many substances in tissue and their metabolism (tissue autoradiography), bonds with submicroscopic structure (electron histochemistry), and enzyme activity. Immunohistochemistry is a promising trend. The most precise histochemical methods, which permit investigation of cell structure, are called cytochemical methods.

The first special histochemical research was done by the French scientist F. Raspail (1825-34). Histochemistry began to develop intensively beginning in the 1940’s, when reliable methods appeared for determining proteins, nucleic acids, lipides, polysaccharides, and certain inorganic components in the cell. By means of histochemical methodology it has been possible, for instance, to show for the first time the connection of changes in the quantity of RNA with the synthesis of protein and the constancy of DNA content in the chromosome bank.


Pearse, E. Gistokhimiia: Teoreticheskaia i prikladnaia. Moscow, 1962. (Translated from English.)
Burstone, M. Gistokhimiia fermentov. Moscow, 1965. (Translated from English.)


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
They used a combination of Cuprolinic blue (which binds to single-stranded RNA) to visualize all neurons and NADPH diaphorase histochemistry, which labels nitrergic neurons (8%-16% of total), almost all of which are situated in the deep submucosa.
Cell surface markers Oct-4, CD105, nanog, CD73 and SSEA-4 are detected positive with immunofluorescence histochemistry on LSCM (laser scanning confocal microscope) (Fig.
The spinning apparatus of Polenecia product (Araneae-Uloboridae): Structure and histochemistry. Zoolomorphology 108:47-59.
The results of histochemistry staining (i) show TRPV1-positive neurons in WT and Pirt knockout mice in CCI models.
Bosch, "Uptake and subcellular distribution of Escherichia coli lipopolysaccharide by isolated rat Type II pneumocytes," Journal of Histochemistry and Cytochemistry, vol.
The glycoprofiling binding of human breast and colon cancer cells, metastasizing or nonmetastasizing, was analyzed by histochemistry using lectins, among these HPA, E-selectin, and P-selectin.
Georgii, "A new histological embedding method by low-temperature polymerisation of methyl methacrylate allowing immuno- and enzyme histochemical studies on semi-thin sections of undecalcified bone marrow biopsies," Histochemistry, vol.
The densitometric analysis of COX histochemistry staining was performed in a similar way; however, the ROD thresholds of hypodense regions were outlined manually, somewhat more arbitrarily, by an experienced observer that was not aware of the treatment protocol.
Among these, FAT is considered to be the gold standard test for the diagnosis of rabies virus yet, histopathology and immune histochemistry are the most reliable and routinely used tests in developing countries.
(6) Methods to determine mucogingival junction are Visual method, Functional method and Visual methods after histochemistry staining.
The journal of histochemistry and cytochemistry: official journal of the Histochemistry Society.