Histoplasma


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Histoplasma

[‚his·tə′plaz·mə]
(mycology)
A genus of parasitic fungi.
References in periodicals archive ?
Fungal lung infections in immunocompromised individuals are caused predominantly by Pneumocystis, Cryptococcus, Aspergillus, Blastomyces, Coccidioides, Histoplasma, Mucor, and rarely, Candida organisms.
Histoplasmosis is a regionally endemic mycosis caused by inhalation of the spores of the fungus Histoplasma capsulatum from the soil, leading occasionally to symptomatic disease and asymptomatic pulmonary nodules (1).
Biopsy of the pinna and oral cavity revealed diffuse, mixed inflammatory infiltrate and numerous epithelioid histiocytes containing small, circular yeast cells compatible with Histoplasma capsulatum (figure 2).
antigen and antibody tests can aid in diagnosis, although clinicians should be aware that these tests have limited sensitivity and can cross-react with Histoplasma capsulatum and other fungi (4).
Levels of serum calcium, vitamin D, and parathyroid hormone were normal, and histoplasma urine antigen was negative.
A direct mycological exam identified fungal elements suggestive of Histoplasma. Histopathological examination demonstrated a granulomatous inflammatory process with massive presence of fungal structures compatible with Histoplasma capsulatum.
Histoplasma capsulatum is an environmental fungus found commonly in the Ohio and Mississippi River valleys in the United States, Central and South America, and Asia [1, 2].
Although the etiology of FM remains unclear, most cases have been related to immune-mediated hypersensitivity reactions to antigens from the fungus Histoplasma capsulatum, which is endemic to North and Central America [1-3].
Two had lung lesions and mediastinal lymph node inflammation due to Histoplasma infection.
Infectious workup was positive for Aspergillus fumigatus IgG, Aspergillus galactomannan antigen (Ag), Histoplasma Ag, Fungitell, and Blastomyces antibody (Ab).
Infectious workup including blood culture, urine culture, CMV, HIV, hepatitis A/B/C serologies, and urine histoplasma antigen was negative.
Isolation of Histoplasma from culture may take up to 12 weeks but can happen as early as 1-2 weeks.