integrase

(redirected from Hiv integrase)
Also found in: Medical.

integrase

[′int·ə‚grās]
(biochemistry)
An enzyme that facilitates prophage integration into or excision from a bacterial chromosome.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Dolutegravir is a second-generation HIV integrase strand transfer inhibitor (INSTI) and the most recent antiretroviral approved for treatment of HIV-1 infection.
Recent safety concerns regarding the newly introduced first-line HIV integrase inhibitor dolutegravir (DTG) have brought necessary attention to the need for pharmacovigilance during pregnancy and breastfeeding.
ViiV Healthcare will seek to prove that Gilead Sciences' triple combination HIV drug containing the HIV integrase inhibitor bictegravir infringes ViiV Healthcare's patent covering ViiV Healthcare's dolutegravir and many other compounds that include dolutegravir's unique chemical scaffold.
Cruz-Mignoni et al., "Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein," Scientific Reports, vol.
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.
Cabotegravir is an HIV integrase inhibitor, rilpivirine a nonnucleoside reverse transcriptase inhibitor.
* The HIV integrase inhibitor dolutegravir increases metformin plasma exposure and may necessitate downward dose adjustment of metformin.
29 October 2012 - Japanese pharmaceutical company Shionogi & Company Ltd (TYO:4507) will take a 10% stake in UK-based HIV drugs maker ViiV Healthcare Ltd in exchange for the transfer of the rights to the HIV integrase inhibitor portfolio of the firms' joint venture to ViiV Healthcare, the companies said.
29 October 2012 a[euro]" Japanese pharmaceutical company Shionogi & Company Ltd (TYO:4507) will take a 10% stake in UK-based HIV drugs maker ViiV Healthcare Ltd in exchange for the transfer of the rights to the HIV integrase inhibitor portfolio of the firms' joint venture to ViiV Healthcare, the companies said.
The product combines the novel HIV integrase inhibitor elvitegravir with a novel "boosting" agent, cobicistat, and Gilead's dual nucleoside/nucleotide reverse transcriptase inhibitor regimen Truvada (emtricitabine/tenofovir).
Since February we have received positive Phase III data on three assets--our HIV integrase inhibitor, Albigutide for diabetes and our B-Raf inhibitor for treatment of melanoma.
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