integrase

(redirected from Hiv integrase)
Also found in: Medical.

integrase

[′int·ə‚grās]
(biochemistry)
An enzyme that facilitates prophage integration into or excision from a bacterial chromosome.
References in periodicals archive ?
ViiV Healthcare will seek to prove that Gilead Sciences' triple combination HIV drug containing the HIV integrase inhibitor bictegravir infringes ViiV Healthcare's patent covering ViiV Healthcare's dolutegravir and many other compounds that include dolutegravir's unique chemical scaffold.
Cabotegravir is an HIV integrase inhibitor, rilpivirine a nonnucleoside reverse transcriptase inhibitor.
29 October 2012 a[euro]" Japanese pharmaceutical company Shionogi & Company Ltd (TYO:4507) will take a 10% stake in UK-based HIV drugs maker ViiV Healthcare Ltd in exchange for the transfer of the rights to the HIV integrase inhibitor portfolio of the firms' joint venture to ViiV Healthcare, the companies said.
29 October 2012 - Japanese pharmaceutical company Shionogi & Company Ltd (TYO:4507) will take a 10% stake in UK-based HIV drugs maker ViiV Healthcare Ltd in exchange for the transfer of the rights to the HIV integrase inhibitor portfolio of the firms' joint venture to ViiV Healthcare, the companies said.
The product combines the novel HIV integrase inhibitor elvitegravir with a novel "boosting" agent, cobicistat, and Gilead's dual nucleoside/nucleotide reverse transcriptase inhibitor regimen Truvada (emtricitabine/tenofovir).
Elvitegravir is an HIV integrase strand transfer inhibitor, a drug that interferes with one of the enzymes that HIV needs to multiply.
Since February we have received positive Phase III data on three assets--our HIV integrase inhibitor, Albigutide for diabetes and our B-Raf inhibitor for treatment of melanoma.
Role of metal ions in catalysis by HIV integrase analyzed using a quantitative PCR disintegration assay.
The drug is part of a class of medications called HIV integrase strand transfer inhibitors that slow the spread of HIV in the body.
Avexa Limited (ASX:AVX) said it has entered into a license agreement with the Shanghai Institute of Organic Chemistry (SIOC) to develop one of Avexa's HIV integrase inhibitor series.
Therefore, we went back to square one and started by looking for a better model of HIV integrase which could be more amenable for crystallization.
New class of HIV integrase inhibitors that block viral replication in cell culture.
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