Nove mogucnosti u TMCH Molecular testing of HLA antigenes
A, B, C, DR, DQ/Molekulsko ispitivanje HLA antigena Family donors, unrelated donors/Porodicni davaoci, nesrodni davaoci Revised indications for HSCT: CML (Glivek et al.), MM (Lenalomid, anti CD38 etc).
The association of HLA antigen
and GVHD in allogeneic hemopoietic stem cell transplantation with histocompatible sibling donor: A single-center experience in Korea.
So, when selecting the best recipient for a donor, becomes more important class ii over class I HLA antigens
Do specific HLA antigens
predispose to ischaemic heart disease or idiopathic dilated cardiomyopathy?
The need to identify sensitization against the donor's HLA antigens
caused the standardization of routine crossmatch prior to any transplant.
The HLA antigens
A2, A32, B18, B44, B60, Cw7, Cw3, Cw5, DR9, DR13, DQ2, DQ3, and DQ6 (antigens of former donors and proven antibody specificities) were given as unacceptable antigens.
A galaxy of old studies have shown and attributed the low HLA detectable antibody levels in the acute myeloid leukemia (AML) patients to the fluctuation kinetics of the HLA antibodies over time2 or more importantly to the what is called immune tolerant".3 That tolerance state can be produced by the exposure of the AML patients to large amounts of the HLA antigens
from the multiple transfusions as shown in vitro and in the murine models.
Case trials have demonstrated the significant associations of particular HLA antigens
and also ABO blood groups with various autoimmune diseases such as juvenile diabetes, multiple sclerosis, rheumatoid arthritis, psoriasis and celiac disease (13-14).
were determined by microcytotoxicity method.
in Behcet's disease: a reappraisal by a comparative study of Turkish and British patients.
Of these, 28 (87%) showed ab against class I HLA antigens
, 16 (50%) against class II, and 12 (38%) tested positive for ab against both class I and class II HLA antigens