human leukocyte antigen

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Related to Hla antigens: Graft versus host disease

human leukocyte antigen

[¦yü·mən ¦lü·kə‚sīt ′ant·i·jən]
(immunology)
Any of a group of antigens present on the surface of nucleated body cells that are coded for by the major histocompatibility complex of humans and thus allow the immune system to distinguish self and nonself. Abbreviated HLA.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Nove mogucnosti u TMCH Molecular testing of HLA antigenes A, B, C, DR, DQ/Molekulsko ispitivanje HLA antigena Family donors, unrelated donors/Porodicni davaoci, nesrodni davaoci Revised indications for HSCT: CML (Glivek et al.), MM (Lenalomid, anti CD38 etc).
The association of HLA antigen and GVHD in allogeneic hemopoietic stem cell transplantation with histocompatible sibling donor: A single-center experience in Korea.
So, when selecting the best recipient for a donor, becomes more important class ii over class I HLA antigens (9).
Do specific HLA antigens predispose to ischaemic heart disease or idiopathic dilated cardiomyopathy?
The HLA antigens A2, A32, B18, B44, B60, Cw7, Cw3, Cw5, DR9, DR13, DQ2, DQ3, and DQ6 (antigens of former donors and proven antibody specificities) were given as unacceptable antigens.
A galaxy of old studies have shown and attributed the low HLA detectable antibody levels in the acute myeloid leukemia (AML) patients to the fluctuation kinetics of the HLA antibodies over time2 or more importantly to the what is called immune tolerant".3 That tolerance state can be produced by the exposure of the AML patients to large amounts of the HLA antigens from the multiple transfusions as shown in vitro and in the murine models.
Case trials have demonstrated the significant associations of particular HLA antigens and also ABO blood groups with various autoimmune diseases such as juvenile diabetes, multiple sclerosis, rheumatoid arthritis, psoriasis and celiac disease (13-14).
HLA antigens were determined by microcytotoxicity method.
HLA antigens in Behcet's disease: a reappraisal by a comparative study of Turkish and British patients.
Of these, 28 (87%) showed ab against class I HLA antigens, 16 (50%) against class II, and 12 (38%) tested positive for ab against both class I and class II HLA antigens.