Hodgkin's disease


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Related to Hodgkin's disease: Huntington's disease

Hodgkin's disease,

a type of cancer of the lymphatic systemlymphatic system
, network of vessels carrying lymph, or tissue-cleansing fluid, from the tissues into the veins of the circulatory system. The lymphatic system functions along with the circulatory system in absorbing nutrients from the small intestines.
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. First identified in 1832 in England by Thomas Hodgkin, it is a type of malignant lymphoma. Incidence peaks in young adults and the elderly. There is some evidence that it is caused by an infection (the Epstein-Barr virusEpstein-Barr virus
(EBV), herpesvirus that is the major cause of infectious mononucleosis and is associated with a number of cancers, particularly lymphomas in immunosuppressed persons, including persons with AIDS.
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 is sometimes present), and studies of twins suggest a hereditary susceptibility. In addition, exposure to the defoliant, Agent OrangeAgent Orange,
herbicide used by U.S. forces during the Vietnam War to expose enemy guerrilla forces in forested areas. Agent Orange contains varying amounts of dioxin. Exposure to the defoliant has been linked with chemical acne, non-Hodgkin's lymphoma, Hodgkin's disease,
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, has been strongly linked to Hodgkin's disease and other lymphomas.

The first sign is often enlarged lymph nodes in the neck or armpit. Lymph node biopsy shows the multinucleated Reed-Sternberg cells peculiar to the disease. It spreads from node to node in an orderly fashion. Symptoms include itching, fever, night sweats, and weight loss. Because it affects the lymphatic system, the body becomes less able to fight off infection as the disease progresses. Radiation therapy and combinations of chemotherapeutic agents are used in treatment. By the 1990s most newly diagnosed cases were curable.

Hodgkin's disease

[′häj·kənz di‚zēz]
(medicine)
A disease characterized by a neoplastic proliferation of atypical histiocytes in one or several lymph nodes. Also known as lymphogranulomatosis.
References in periodicals archive ?
29] Other studies have shown that rates of cure and relapse-free survival following combination chemotherapy were comparable to those of radiation therapy alone in early-stage Hodgkin's disease.
There are approximately 1,300 new cases of Hodgkin's disease in the UK each year, with 150 of those cases involving children.
Immunohistochemical detection of Epstein-Barr virus-encoded latent membrane protein in Reed-Sternberg cells and variants of Hodgkin's disease.
Rubio R, for the Cooperative Study Group of Malignancies Associated with HIV Infection of Madrid: Hodgkin's disease associated with human immunodeficiency virus infection.
Kim said he has talked to oncologists all over the world who have assured him that the chance of metastasis to the ovarian tissue is extremely rare in women with Hodgkin's disease.
Six months later, Markazi found out he, too, had Hodgkin's disease.
The story, a best seller about a jester who searches the world for laughter, was written by Saltzman's son, David, who died of Hodgkin's disease at the age of 22.
Seattle Genetics is developing its own ADC product candidates, including SGN-35, which entered clinical trials in 2006 for patients with Hodgkin's disease and other CD30-positive malignancies, and SGN-75, which is in preclinical development for renal cell cancer and CD70-positive hematologic malignancies.
Madrid, 44, said she suffers from Hodgkin's disease and her younger sister who now lives in Florida suffers from Crohn's disease.
The 44-year-old Burbank resident said she wants to hold Lockheed responsible for her Hodgkin's disease, as well as other illnesses in her family.
A laptop computer topped the wish list of 14-year-old Simi Valley resident Justin Mikita, who has been undergoing chemotherapy for Hodgkin's disease.
Seattle Genetics presented data from two phase II clinical studies of SGN-30, a monoclonal antibody directed against the CD30 antigen, which is highly expressed on a variety of hematologic malignancies including Hodgkin's disease and some T-cell non-Hodgkin's lymphomas.