Hodgkin's disease


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Related to Hodgkin's disease: Huntington's disease

Hodgkin's disease,

a type of cancer of the lymphatic systemlymphatic system
, network of vessels carrying lymph, or tissue-cleansing fluid, from the tissues into the veins of the circulatory system. The lymphatic system functions along with the circulatory system in absorbing nutrients from the small intestines.
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. First identified in 1832 in England by Thomas Hodgkin, it is a type of malignant lymphoma. Incidence peaks in young adults and the elderly. There is some evidence that it is caused by an infection (the Epstein-Barr virusEpstein-Barr virus
(EBV), herpesvirus that is the major cause of infectious mononucleosis and is associated with a number of cancers, particularly lymphomas in immunosuppressed persons, including persons with AIDS.
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 is sometimes present), and studies of twins suggest a hereditary susceptibility. In addition, exposure to the defoliant, Agent OrangeAgent Orange,
herbicide used by U.S. forces during the Vietnam War to expose enemy guerrilla forces in forested areas. Agent Orange contains varying amounts of dioxin. Exposure to the defoliant has been linked with chemical acne, non-Hodgkin's lymphoma, Hodgkin's disease,
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, has been strongly linked to Hodgkin's disease and other lymphomas.

The first sign is often enlarged lymph nodes in the neck or armpit. Lymph node biopsy shows the multinucleated Reed-Sternberg cells peculiar to the disease. It spreads from node to node in an orderly fashion. Symptoms include itching, fever, night sweats, and weight loss. Because it affects the lymphatic system, the body becomes less able to fight off infection as the disease progresses. Radiation therapy and combinations of chemotherapeutic agents are used in treatment. By the 1990s most newly diagnosed cases were curable.

Hodgkin's disease

[′häj·kənz di‚zēz]
(medicine)
A disease characterized by a neoplastic proliferation of atypical histiocytes in one or several lymph nodes. Also known as lymphogranulomatosis.
References in periodicals archive ?
Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswolds meeting.
Expression status of BCL-6 and syndecan-1 identifies distinct histogenetic subtypes of Hodgkin's disease. Blood.
The aim of this study was to investigate the variables which influence survival by examining survival times and reponse to treatment in pediatric patients with Hodgkin's disease. With this objective demographic, clinical, laboratory variables and histopathological data were examined.
Bone marrow bio- psy in Hodgkin's disease. Indian J Pathol Microbiol 2004; 47 (3): 346-347.
Transient reversal of bone marrow aplasia associated with lymphocyte depleted Hodgkin's disease after combination chemotherapy.
When Hodgkin's disease is suspected, microscopic histological examination of the lymph nodes through a biopsy helps to classify the Hodgkin's.
Drawing on estimates from scientific literature and data from the International Agency of Research on Cancer, this slim monograph reports the incidence of Hodgkin's disease on different continents by age group and gender.
This season's dinner raised over $700,000 for the charity seeking to cure Leukemia, lymphoma, Hodgkin's disease and myeloma and to improve the quality of life for patients and their families.
Chen and her associates have done cardiovascular disease follow-up studies on 182 patients in the Hodgkin's Disease Cardiac Study.
NEW YORK--Heart disease is the leading cause of noncancer mortality in patients who survive an initial bout with Hodgkin's disease, an example of the importance of monitoring for heart disease in cancer survivors.
NEW YORK -- The relative risk for cardiovascular disease is about two- to sevenfold higher in Hodgkin's disease survivors compared with age- and gender-matched people with no cancer history, Dr.