Hodgkin's disease

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Hodgkin's disease,

a type of cancer of the lymphatic systemlymphatic system
, network of vessels carrying lymph, or tissue-cleansing fluid, from the tissues into the veins of the circulatory system. The lymphatic system functions along with the circulatory system in absorbing nutrients from the small intestines.
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. First identified in 1832 in England by Thomas Hodgkin, it is a type of malignant lymphoma. Incidence peaks in young adults and the elderly. There is some evidence that it is caused by an infection (the Epstein-Barr virusEpstein-Barr virus
(EBV), herpesvirus that is the major cause of infectious mononucleosis and is associated with a number of cancers, particularly lymphomas in immunosuppressed persons, including persons with AIDS.
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 is sometimes present), and studies of twins suggest a hereditary susceptibility. In addition, exposure to the defoliant, Agent OrangeAgent Orange,
herbicide used by U.S. forces during the Vietnam War to expose enemy guerrilla forces in forested areas. Agent Orange contains varying amounts of dioxin. Exposure to the defoliant has been linked with chemical acne, non-Hodgkin's lymphoma, Hodgkin's disease,
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, has been strongly linked to Hodgkin's disease and other lymphomas.

The first sign is often enlarged lymph nodes in the neck or armpit. Lymph node biopsy shows the multinucleated Reed-Sternberg cells peculiar to the disease. It spreads from node to node in an orderly fashion. Symptoms include itching, fever, night sweats, and weight loss. Because it affects the lymphatic system, the body becomes less able to fight off infection as the disease progresses. Radiation therapy and combinations of chemotherapeutic agents are used in treatment. By the 1990s most newly diagnosed cases were curable.

Hodgkin's disease

[′häj·kənz di‚zēz]
A disease characterized by a neoplastic proliferation of atypical histiocytes in one or several lymph nodes. Also known as lymphogranulomatosis.
References in periodicals archive ?
Brentuximab vedotin is a highly effective drug with an adequate safety profile that fills an unmet therapeutic need in patients with CD30-positive relapsed or refractory Hodgkin's lymphoma or relapsed or refractory ALCL, said Dr.
HL is classified according to the WHO Classifi- cation, which is the reviewed REAL classification in- to a) Classical Hodgkin's lymphoma, which includes Nodular Sclerosis, Lymphocyte Depletion, Lympho- cyte Rich and Mixed Cellualrity HL and b) Lympho- cyte Predominance as a separate entity.
The patients of Hodgkin's Lymphoma diagnosed on tis- sue biopsy (nodal and extra nodal) were included in the study.
Hodgkin's lymphoma is characterized by the orderly spread of disease from one lymph node group to another and by the development of systemic symptoms with advanced disease.
There are very few studies that have analyzed Hodgkin's lymphoma during the HAART era, (10,20,24) so assessing the incidence of this malignancy in HIV-infected patients since the introduction of HAART has been difficult.
In non-HIV-infected patients with Hodgkin's lymphoma, CD4 T cells predominate in the tumor microenvironment and may contribute, at least in part, to the modulation of the Hodgkin's lymphoma phenotype (46) and eventually to its clinical behavior.
DISCUSSION: Thomas Hodgkin offered the first description of Hodgkin's lymphoma in 1832, in a paper titled "On some morbid appearances of the absorbent glands and spleen" (4, 5).
Association of Epstein Barr virus infection to classical Hodgkin's lymphoma is prominent in children from developing countries with an incidence of 91-98%.
The report provides information on the key drivers and challenges of the Hodgkin's Lymphoma Therapeutics market.
Annualized seven key markets (US, France, Germany, Italy, Spain, UK and Japan) Hodgkin's Lymphoma Therapeutics market revenues data from 2005 to 2009, forecast for eight years to 2017.
DISCUSSION: The maxillary sinus is a rare anatomic site for the presence of Hodgkin's lymphoma.
Hodgkin's Lymphoma is a cancer that starts in lymphatic tissue, most often in lymph nodes in the upper part of the body such as within the chest, neck or underarms.