Hofmann amine separation

Hofmann amine separation

[′häf·mən ′am‚ēn ‚sep·ə‚rā·shən]
(organic chemistry)
A technique to separate a mixture of primary, secondary, and tertiary amines; they are heated with ethyl oxalate; there is no reaction with tertiary amines, primary amines form a diamide, and the secondary amines form a monoamide; when the reaction mixture is distilled, the mixture is separated into components.