Homogentisic Acid


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homogentisic acid

[¦hä·mə‚jen¦tiz·ik ′as·əd]
(biochemistry)
C8H8O4 An intermediate product in the metabolism of phenylalanine and tyrosine; found in excess in persons with phenylketonuria and alkaptonuria.

Homogentisic Acid

 

an intermediate product of the decomposition of the cyclic amino acids phenylalanine and tyrosine in the animal or human body. In the hereditary disease alkaptonuria, which is expressed in a disturbance of the metabolism of these amino acids, the process stops at the stage of homogentisic acid formation because of an absence of homogentisic acid oxidase, and homogentisic acid is discharged with the urine.

References in periodicals archive ?
Therapeutic method include mega dose of vitamin C (upto 1 gm /day) for the degradation of homogentisic acid.
Gallic acid, pyrogallol, homogentisic acid, protocatechuic acid, (+) catechin, chlorogenic acid, caffeic acid, vanillin, ferulic acid, naringin, resveratrol, naringenin, hesperetin, formononetin and biochanin-A were used as standard for the detection of phenolic compounds from the fruiting bodies of P.
Sbou' explained that Alkaptonuria is caused by deficiency of the enzyme homogentisic acid oxidase (HGO), as a consequence of the enzymatic block, the homogentisic acid (HGA) accumulates in body tissues, vertebrae, joints and heart valves,.
Importantly, neither melanin nor homogentisic acid are detected in a routine urinalysis, therefore careful attention to the color of urine can provide an important clue to an underlying disease process.