homovanillic acid

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homovanillic acid

[¦hä·mə·və¦nil·ik ′as·əd]
(biochemistry)
HOC6H3(OCH3)CH2CO2H A major metabolite of 3-O-methyl dopa; used in enzyme determination. Abbreviated HVA.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Determination of homovanillic acid in urine by stable isotope dilution and electrospray tandem mass spectrometry.
Among these were hippuric acid, homovanillic acid, uracil, 5-fluorouracil, and tryptophan.
Currently this technology is being used in laboratories for assays such as homocysteine, 17-hydroxyprogesterone, urine catecholamines, vanillylmandelic acid, homovanillic acid, and urine metanephrines (21-25).
This is essential when investigating certain neurotransmitters, for example, the monoamine metabolites homovanillic acid and 5-hydroxy-indoleacetic acid, for which marked concentration gradients have been found (47), but also when investigating proteins such as albumin and immunoglobulins (26).
Our laboratory recently described LC-MS/MS methods for total homocysteine (16), methylmalonic acid (17), and homovanillic acid (18) as well as for glycosylated transferrin (19), which are currently being used in the clinical laboratory.
Low CSF concentrations of homovanillic acid and 5-hydroxyindoleacetic acid, metabolites of dopamine and serotonin, respectively, are found in all variants of B[H.sub.4] deficiencies.
Rapid and reliable high-performance liquid chromatographic method for analyzing human plasma 5-HT, 5-hydroxyindoleacetic acid, homovanillic acid and 3,4-dihydroxyphenylacetic acid.
The neurotransmitter metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy4-hydroxyphenylglycol (MHPG) in CSF and 5-HIAA, HVA, and vanillylmandelic acid (VMA) in urine were measured with HPLC and electrochemical detection, and the metabolites 3-o-methyldopa and L-dopa in CSF and dopamine, epinephrine, and norepinephrine in urine were measured with HPLC and fluorometric detection.
In contrast, no consistent differences in urine concentrations of homovanillic acid, a major urine DA metabolite, were found after exposure to concentrated particles (Liu et al.
Two cases had incidental finding of markedly elevated homovanillic acid (HVA) excretion in the urine.
An unequivocal pathological diagnosis from tumor tissue is made by light microscopy, with or without immunohistochemistry (IHC) or raised urine/serum homovanillic acid (HVA) or vanillylmandelic acid (VMA).
West, "Concomitant fall in brain dopamine and homovanillic acid in hydrocephalic rabbits," Experimental Neurology, vol.