Demonstrating the hormetic
benefit of this response in a variety of brain cells, overexpression of PGC-1[alpha] protected against cell death induced by [H.sub.2][O.sub.2] or paraquat treatment, and this occurred in conjunction with changes in gene expression similar to those observed with the 10T1/2 cells .
Berberine displays hormetic
effects "in vitro." It has been shown that berberine at low-dose range (1.25 ~ 5 [micro]M) can promote cell proliferation while at high-dose range (10 ~ 80 [micro]M) can inhibit cell proliferation .
Other researchers demonstrated using cell cultures that low doses of ionizing photon radiation (x-rays, gamma rays) can lead to a reduction in the neoplastic transformation frequency to below the spontaneous level, (46-49) while high doses led to elevated transformation frequencies that increase as the radiation dose increases (i.e., a hormetic
Biological Stress Response Terminology: Integrating the Concepts Adaptive Response and Preconditioning Stress with a Hormetic
concentrations of hydrogen peroxide but not ethanol induce cross-adaptation to different stresses in budding yeast," International Journal of Microbiology, vol.
Pentachlorophenol had a hormetic
behavior, inducing gamma-H2AX foci in the lowest concentrations, whereas the effect diminished in the highest (Table 2).
Pan et al., "Hormetic
response to low-dose radiation: focus on the immune system and its clinical implications," International Journal of Molecular Sciences, vol.
influence of glucocorticoids on human memory," Nonlinearity in Biology, Toxicology, Medicine, vol.
Shama, "Process challenges in applying low doses of ultraviolet light to fresh produce for eliciting beneficial hormetic
responses," Postharvest Biology and Technology, vol.
According to a study by Perez et al., nonthermal repetitive EMF shocks induce an antiaging hormetic
effect and reduce cell death in T lymphocytes and fibroblast cell lines during lethal stress .
Rattan, "Modulating cellular aging in vitro: hormetic
effects of repeated mild heat stress on protein oxidation and glycation," Experimental Gerontology, vol.
Menendez, "Metformin and cancer: doses, mechanisms and the dandelion and hormetic
phenomena," Cell Cycle, vol.