Conversely, there was little increased risk of breast cancer after using any form of hormone therapy
for less than a year, the researchers said.
Still, the important takeaway is that trans women--who are one of the most marginalized and vulnerable populations in terms of HIV--can safely continue their hormone therapy
and protect their health with PrEP.
The effect of hormone therapy
on breast cancer risk is complex and conflicting, noting that breast cancer risk from HT may depend on many factors, including whether progestins are added to estrogen, the dose and duration of HT use, and how HT is administered.
It was also noted that women with a score of 0-10 had very low recurrence rates with hormone therapy
alone at nine years (3%) while women with a score of 26-100 had distant recurrence rate of 13%, despite receiving both hormone therapy
"The effect of hormone therapy
on breast cancer risk is complex and conflicting," said Dr Pinkerton, noting that breast cancer risk from HT may depend on many factors, including whether progestins are added to estrogen, the dose and duration of HT use, and how HT is administered.
Comparatively, 83% of men assigned abiraterone therapy survived versus 76% of men on standard hormone therapy
Editor's Note: Past users had higher bone mineral density at the lumbar spine and hip and a trend toward higher trabecular bone scores than those who had never used hormone therapy
Many women are prescribed hormones like synthetic estrogen and progestin starting in their teens (in the form of hormone-based contraceptives), continuing through the menopausal transition (in the form of menopause hormone therapy
), and even later years (in the form of estrogen therapy).
Eligible studies have information on hormone therapy
use, parity, oophorectomy and hysterectomy.
"In prostate cancer it has been used at a much more advanced stage of the illness, for some years - now we know that this chemotherapy should be added earlier, in fact as soon as hormone therapy
Additionally, all types of hormone therapy
had similar rates of total cardiovascular outcomes and all-cause mortality, the study showed.