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[′hō·mē·ə‚bäks]
(cell and molecular biology)
A highly conserved sequence of deoxyribonucleic acid (DNA) that occurs in the coding region of development-controlling regulatory genes and codes for a protein domain that is similar in structure to certain DNA-binding proteins and is thought to be involved in the control of gene expression during morphogenesis and development.
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References in periodicals archive ?
The HOX gene cluster in the bivalve mollusc Mytilus galloprovincialis.
The homology of the Hox genes across hundreds of millions of years of evolution, and between highly divergent phylogenies, (41) suggests an astounding degree of sequence stability and preserved function.
Hox genes act in synergy and in different temporal patterns, and no single function can be ascribed to a single gene.
Not only did Rinn locate many previously unknown ncRNA genes nestled among the HOX genes, he also identified areas that serve as shared landing pads for proteins that either activate or suppress the neighboring regions.
In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing Miillerian system.
A few years ago, Duboule discovered in these animals a defect in the Hox gene that normally stops the vertebrae-making process.
Functional assays of the Hox gene Ubx were performed using RNA interference (Liubicich et al.
These genes have remained relatively unchanged throughout evolutionary history, and the complex may have evolved from a single ancestral hox gene.
Perhaps the most widely known example of the conservation of these genes is that of the Hox gene complex.
The Hox gene complement of acoel flatworms, a basal bilaterian clade.