The HOX gene
cluster in the bivalve mollusc Mytilus galloprovincialis.
The homology of the Hox genes
across hundreds of millions of years of evolution, and between highly divergent phylogenies, (41) suggests an astounding degree of sequence stability and preserved function.
, neural crest cells and branchial arch patterning.
act in synergy and in different temporal patterns, and no single function can be ascribed to a single gene.
Not only did Rinn locate many previously unknown ncRNA genes nestled among the HOX genes
, he also identified areas that serve as shared landing pads for proteins that either activate or suppress the neighboring regions.
In utero diethylstilbestrol (DES) exposure alters Hox gene
expression in the developing Miillerian system.
A few years ago, Duboule discovered in these animals a defect in the Hox gene
that normally stops the vertebrae-making process.
Functional assays of the Hox gene
Ubx were performed using RNA interference (Liubicich et al.
These genes have remained relatively unchanged throughout evolutionary history, and the complex may have evolved from a single ancestral hox gene
Perhaps the most widely known example of the conservation of these genes is that of the Hox gene
In AML with MLL-PTD, aberrant expression of downstream Hox gene
plays an etiologic role in the MLL-PTD gain of function and leukemogenesis of AML.
The Hox gene
complement of acoel flatworms, a basal bilaterian clade.