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[′hō·mē·ə‚bäks]
(cell and molecular biology)
A highly conserved sequence of deoxyribonucleic acid (DNA) that occurs in the coding region of development-controlling regulatory genes and codes for a protein domain that is similar in structure to certain DNA-binding proteins and is thought to be involved in the control of gene expression during morphogenesis and development.
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In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing Miillerian system.
"Hox genes are situated one exactly after the other on the DNA strand, in four groups.
To address this hypothesis, the evaluation of Hox gene expression patterns may be informative since modifications to Hox gene expression patterns or functions have been linked to changes in the morphologies and functions of appendages.
We can also have Hox genes generating contexts or "fields" in this manner.
Qin, "Nonstructural protein-1 of respiratory syncytial virus regulates HOX gene expression through interacting with histone," Molecular Biology Reports, vol.
In a series of biochemical experiments they further showed that Hoxc9 orchestrates gene expression in motor neurons by repressing the Hox genes dedicated to limb coordination.
This is supported by several studies on RNA sequences (see, for example, Giribet et al, 2007) and also by observations on the distribution of Hox genes (see below) and microRNAs (Sempere et al, 2007).
Therefore, specification of differentiation fate along the anterior-posterior axis by Hox genes need not have evolved independently in Protostomia and Deuterostomia, as required under Nielsen's rendition of the larval-first hypothesis.
The study adds to emerging evidence that Hox genes, which are largely the same in all vertebrate species, influence biology and behavior in a surprisingly wide variety of ways, he adds.
These differences allow the evolutionary validity of proposed relationships between Hox gene expression, neuronal identity, and behavior to be tested; they also allow us to determine whether the anatomical divergence of elasmobranchs reflects only relatively slight differences in a common vertebrate morphogenetic plan, or a more radical reorganization undertaken specifically by elasmobranchs, but masked by similarities in oculomotor behaviors.
The identity of the posterior mesotroch with the aliform notopodia of setiger B1 can be inferred from Hox gene expression patterns (Irvine, 1998; Irvine and Martindale, 1999b).
Studies of fruitflies and mice have shown that a certain group of genes (otd and ems in flies, and their vertebrate orthologues Otx and Emx) encode transcription factors that are expressed predominately in head structures - anterior to the boundary of Hox gene expression - in both of these disparate taxa (6).