homeobox

(redirected from Hox genes)
Also found in: Dictionary, Thesaurus, Medical.

homeobox

[′hō·mē·ə‚bäks]
(cell and molecular biology)
A highly conserved sequence of deoxyribonucleic acid (DNA) that occurs in the coding region of development-controlling regulatory genes and codes for a protein domain that is similar in structure to certain DNA-binding proteins and is thought to be involved in the control of gene expression during morphogenesis and development.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
Mentioned in ?
References in periodicals archive ?
Percival-Smith, "Acquisition of a leucine zipper motif as a mechanism of antimorphy for an allele of the Drosophila Hox gene sex combs reduced," G3: Genes, Genomes, Genetics, vol.
HOXA9 is one of the most abundant HOX genes in HSCs.
Testosterone and progesterone have been shown to regulate HOX gene expression [8].
Nanog and Hox genes each have their own distinct jobs and by inhibiting each other they work together to direct the proper balance of cell states by helping the cell avoid wrong turns and stay on course.
To visualize the expression of all 39 HOX genes, hierarchical clustering was applied (MEV4.0, Boston, MA, USA).
The orthological assignments of these new Hox genes were determined by phylogenetic analyses by the ML (Fig.
Hox genes indicate a degree of hierarchical organization, context-sensitivity as defined in the terms of the Chomsky hierarchy (see O Nuallain 2003) and long-distance dependencies, indicating that perhaps the phenomena Shieber remarked on are present also in the genome.
Moreover, hth is also expressed in cells where Hox genes are not expressed; for example, we showed that the Hth-YFP protein trap is expressed in the hinge and notum regions (but not the pouch) of the wing disc where no Hox genes, including Ubx, are significantly expressed [27].
found that both gene expression and methylation patterns were altered, proposing that DNMT3A mutations gave rise to hypomethylation of HOX genes [39].
Human genes called the Hox genes have the same pattern of organization, follow the same order of gene arrangement, their expressions and functions are also in sequences as observed in Drosophila.The genes HOX A,HOX B, HOX C and HOX D are arranged on four different chromosomes 7,17,12 and 2.