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Messenger RNA expression of all 3 HOX genes (HOXC4, HOXC5, and HOXC6) has been detected in ALCL and C-ALCL, with HOXC5 being most strongly expressed in C-ALCL, (322) suggesting a role in the cutaneous location of this tumor.
HOXC4, HOXC5, and HOXC6 expression in non-Hodgkin's lymphoma: preferential expression of the HOXC5 genein primarycutaneousanaplasticT-cell andoro-gastrointestinal tract mucosa-associated B-cell lymphomas.
The genes that were more highly expressed in carcinomas treated with androgen ablation agents included those encoding AR and steroid biosynthetic enzymes, as well as a suite of genes that have been previously shown to be targets of AR or have been implicated as being regulated by it, including the gene encoding PSA (kallikrein-related peptidase 3), KLK3, and KLK2, as well as DBI, FASN, IL6, SERPINB5, TGFBR3, TMPRSS2, TUBA1, HOXC6, TRG ,and FOLH1.