human papillomavirus

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human papillomavirus

(HPV), any of a family of more than 60 viruses that cause various growths, including plantar wartswart,
circumscribed outgrowth of the skin caused by a filterable virus that is readily transmitted. Warts may appear anywhere on the skin but are most common on the hands.
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 and genital warts, a sexually transmitted diseasesexually transmitted disease
(STD) or venereal disease,
term for infections acquired mainly through sexual contact. Five diseases were traditionally known as venereal diseases: gonorrhea, syphilis, and the less common granuloma inguinale, lymphogranuloma venereum, and
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. Detectable warts can be or removed, usually by chemicals, freezing, or laser, but often recur. Intralesional alpha interferon has been effective in the treatment of genital warts. Genital warts, sometimes called condylomata acuminata, are soft and often occur in clusters. They can occur internally or externally, but even in the absence of warts the virus may be present and transmittable. Problems can result from untreated warts, which can grow quite large, or, in rare cases, from infection of an infant during delivery. In addition, certain strains of HPV are associated with cancercancer,
in medicine, common term for neoplasms, or tumors, that are malignant. Like benign tumors, malignant tumors do not respond to body mechanisms that limit cell growth.
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 of the cervix, vulva, vagina, penis, and anus, and HPV 16 has been shown to be associated with some forms of Kaposi's sarcoma (see AIDSAIDS
or acquired immunodeficiency syndrome,
fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. It was first recognized as a disease in 1981.
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) and throat cancer. A vaccine approved by the Food and Drug Administration in 2006 can protect a woman against those strains that cause most cases of cervical cancer and genital warts, and a study has shown it may also protect against related throat cancers; HPV vaccination is now recommended for both girls and boys beginning at 11 to 12 years of age.

human papillomavirus

[¦yü·mən ‚pap·ə′lō·mə ‚vī·rəs]
(medicine)
One of a family of more than 100 different viruses, most commonly spread via sexual contact, that cause warts on the hands and feet and in the genital area; several types are associated with premalignant and malignant changes in the cervix. Abbreviated HPV.
References in periodicals archive ?
HPV DNA test and Pap smear in detection of residual and recurrent disease following loop electrosurgical excision procedure of high-grade cervical intraepithelial neoplasia.
Another development is a new HPV DNA test, called careHPV, which is less expensive and requires less infrastructure than either conventional DNA or Pap tests and offers rapid test results.
Neophytou said HPV DNA tests could be carried out at any clinical laboratory.
The American Cancer Society notes that women over 30 have the option of dual screening--a Pap and an HPV DNA test.
In the light of new data concerning the epidemiology and natural history of HPV and the availability of the liquid-based Pap tests and HPV DNA test, new guidelines for Pap screening and management of abnormal cytologic findings have been developed with input from professional organizations.
In addition, the Food and Drug Administration recently approved the use of a commercially available HPV DNA test for two purposes: 1) management of patients with abnormal Pap test results and 2) as an adjunct to the Pap test for cervical cancer screening in women aged [greater than or equal to] 30 years.
A recently published study comparing three FDA-approved screening tests for human papillomavirus (HPV) provides the latest confirmation of superior sensitivity for QIAGEN s digene HC2 HPV DNA Test.
Although these eight studies differed significantly in the composition of the referral population for colposcopy (the majority enrolling women with abnormal cytology of any grade), the absolute clinical sensitivity of RealTime, as well as its sensitivity relative to the clinically validated comparator test Hybrid Capture[R] 2 HPV DNA Test (HC2) (Qiagen, Hilden, Germany), were consistently high for both CIN2+ and CIN3+ in all studies performed to date (Table 1).
More than 8,600 Danish women, 20 to 29 years old at enrollment, were tested twice, 2 years apart, for HPV by the Hybrid Capture 2 High-Risk (HC2 HR) HPV DNA Test (Qiagen) and byline-blot assays for type-specific HPV.
A high-risk human papillomavirus (HPV) DNA test that detects cancer-causing HPV types is generally used for screening and managing women with abnormal Pap test results, but there are no clinical recommendations for use of a low-risk HPV DNA test that detects five nononcogenic HPV types, said Jennifer Wai-Yin Lee, R.