cytomegalovirus

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cytomegalovirus

(sī'təmĕg'əlōvī`rəs), member of the herpesvirus family that can cause serious complications in persons with weakened immune systems and infants. A common virus, it is estimated that up to 80% of Americans carry cytomegalovirus by the time they reach adulthood. Most experience no symptoms or mild symptoms such as enlarged lymph nodes, low fever, and fatigue that may or may not be noticed. Cytomegalovirus is present in body fluids (saliva, semen, cervical secretions, and urine) and can be spread from person to person by sexual contact, kissing, or the sharing of food. It can also be transmitted from mother to fetus. The virus usually remains dormant in the body, but it can reactivate and cause serious symptoms in immunologically suppressed patients, such as those with AIDSAIDS
or acquired immunodeficiency syndrome,
fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. It was first recognized as a disease in 1981.
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, or in infants whose immune systems are not yet fully developed. An estimated 25% of AIDS patients experience CMV infection, often in the form of a viral retinitis that can lead to blindness. Infants can become infected before birth when the mother becomes infected or experiences a recurrence during pregnancy. In a newborn, CMV can be life-threatening, and it can lead to later complications such as cerebral palsy, blindness, hearing problems, mental retardation, and learning disabilities. The antiviral drugs foscarnet and ganciclovir are used to keep active infections under control.

cytomegalovirus

[¦sīd·ō¦meg·ə·lō′vī·rəs]
(virology)
An animal virus belonging to subgroup B of the herpesvirus group; causes cytomegalic inclusion disease and pneumonia.
References in periodicals archive ?
Conclusion: Routine monitoring during the first three post-transplant months has a positive impact on the early detection of Human cytomegalovirus viral replication allowing for timely treatment in order to reduce morbidity of the disease.
Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target.
Human cytomegalovirus pp67 mRNAemia versus pp65 antigenemia for guiding preemptive therapy in heart and lung transplant recipients: a prospective, randomized, controlled, open-label trial.
The research objective was to identify clinical manifestation of HCMV in 100 children, ages ranging from seven days to six months, with a human cytomegalovirus infection.
Continuous human cytomegalovirus seroconversion in a large group of healthy donors.
According to the previous reports, human cytomegalovirus (HCMV) down-regulates the surface expression of MHC class I molecules (Del et al.
Human cytomegalovirus (HCMV) poses an important public health problem as it is associated with infections in the immunocompromised, including transplant recipients and HIV infected individuals, as well as with congenital infections.
Among their topics are human cytomegalovirus infections and mechanisms of disease, virus entry and activation of innate immunity, the antibody-mediated neutralization of infectivity, determinants of macrophage tropism, the rat model for infection and vascular diseases, and current perspectives on vaccine development.
The study and monitoring of human cytomegalovirus (CMV) is one of the most advanced applications of tetramer technology.

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