cytomegalovirus

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cytomegalovirus

(sī'təmĕg'əlōvī`rəs), member of the herpesvirus family that can cause serious complications in persons with weakened immune systems and infants. A common virus, it is estimated that up to 80% of Americans carry cytomegalovirus by the time they reach adulthood. Most experience no symptoms or mild symptoms such as enlarged lymph nodes, low fever, and fatigue that may or may not be noticed. Cytomegalovirus is present in body fluids (saliva, semen, cervical secretions, and urine) and can be spread from person to person by sexual contact, kissing, or the sharing of food. It can also be transmitted from mother to fetus. The virus usually remains dormant in the body, but it can reactivate and cause serious symptoms in immunologically suppressed patients, such as those with AIDSAIDS
or acquired immunodeficiency syndrome,
fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. It was first recognized as a disease in 1981.
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, or in infants whose immune systems are not yet fully developed. An estimated 25% of AIDS patients experience CMV infection, often in the form of a viral retinitis that can lead to blindness. Infants can become infected before birth when the mother becomes infected or experiences a recurrence during pregnancy. In a newborn, CMV can be life-threatening, and it can lead to later complications such as cerebral palsy, blindness, hearing problems, mental retardation, and learning disabilities. The antiviral drugs foscarnet and ganciclovir are used to keep active infections under control.

cytomegalovirus

[¦sīd·ō¦meg·ə·lō′vī·rəs]
(virology)
An animal virus belonging to subgroup B of the herpesvirus group; causes cytomegalic inclusion disease and pneumonia.
References in periodicals archive ?
Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target.
Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action.
Molecular pathogenesis of human cytomegalovirus infection.
Androgen-dependent activation of human cytomegalovirus major immediate-early promoter in prostate cancer cells.
Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood.
Human cytomegalovirus UL 144 open reading frame: Sequence hypervariability in low passage clinical isolates.
Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors.
Quantitation of human cytomegalovirus (HCMV) DNA in cerebrospinal fluid by competitive PCR in AIDS patients with different HCMV central nervous system diseases.
The test is traceable to the first WHO International Standard for Human Cytomegalovirus for Nucleic Acid Amplification Techniques (NIBSC 09/162) and reliably monitors cytomegalovirus (CMV) infections and the effect of antiviral therapy on viral activity.
CMX001 is currently in Phase 2 clinical trials for prophylaxis of human cytomegalovirus infection and under development using the FDA's "Animal Rule" for smallpox infection.
The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration.
The present Competitive Intelligence Report about CMV Vaccines & Therapeutics provides a competitor evaluation in the field of prophylactic vaccines and therapeutic antibodies, antisense, proteins, cells and small molecules against infection with human Cytomegalovirus (CMV) as of August 2012.

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