genome

(redirected from Human genome)
Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.
Related to Human genome: Human Genome Organization

genome:

see geneticsgenetics,
scientific study of the mechanism of heredity. While Gregor Mendel first presented his findings on the statistical laws governing the transmission of certain traits from generation to generation in 1856, it was not until the discovery and detailed study of the
..... Click the link for more information.
.

genome

the overall genetic constitution of an organism/species as constituted by the chromosomal makeup of every member (the term arises from a combination of the terms ‘gene’ and ‘chromosome’). See also GENETICS, HUMAN GENOME PROJECT.

Genome

 

a haploid chromosome set; the sum total of the genes localized in the individual set of chromosomes of a given organism. The term was introduced in 1920 by the German biologist H. Winkler. The genome is usually understood to mean the sum of the genes concentrated in the chromosomes, without taking into account the hereditary determinants connected with the structures of cytoplasm. In the gametes of diploid organisms, as well as in the cells of haploid organisms, there is one genome; in the somatic cells of diploid organisms there are two genomes. With an increase in ploidy of the cells, the number of genomes grows. In fertilization, the genomes of the paternal and maternal gametes unite. As a rule, genomes obtained from paternal and maternal gametes are homologous. Homology between all or some genomes exists in all but distant hybrids. Absolute homology of two genomes may be defined as the coinciding of the linear arrangement of the genes in every chromosome. This coinciding ensures the possibility of the normal conjugation of chromosomes in meiosis.

Changes in the number of chromosomes (for example, polyploidy or an increase or loss of individual chromosomes) are called genomic mutations. An organism in which one and the same genome is repeated several times is called au-topolyploid. An organism in which different genomes are combined is called allopolyploid. Wheats may serve as an example of the allopolyploids. The haploid number of chromosomes in hard wheat is 14, in soft wheat, 21; and in einkorn, seven. By hybridization and the study of the conjugation of chromosomes in meiosis, it was ascertained that in all wheats there is one common genome (genome A) made up of seven chromosomes. In hard and soft wheat there are two common genomes (genomes A, B), each having seven chromosomes. Finally, in soft wheat, there is still another special genome (genome D), also made up of seven chromosomes. Thus, the genomic formula for einkorn is AA and for hard wheat it is AABB. Soft wheat, which has arisen in the process of evolution by the crossing of three different wild cereals and by the doubling of the number of chromosomes in the hybrids, has the genomic formula AABBDD.

In the experiments of the Soviet geneticist G. D. Kar-pechenko, radish and cabbage genomes were combined for the first time in a hybrid organism. By means of corresponding crossings and cytological analysis, the origin of separate genomes can be established. For example, V. A. Rybin obtained (resynthesized) a cultivated plum by crossing the cherry plum and the sloe; thus it was established that the genome of a plum includes cherry plum and sloe genomes. Of great significance in understanding the structure and functioning of the genome have been the establishment of the structure of the molecules of nucleic acids (DNA and RNA) and of the mechanisms of their replication, and the establishment of the means of “tracing” and transmitting genetic information.

V. N. SOIFER and V. V. KHVOSTOVA

genome

[′jē‚nōm]
(genetics)
The genetic endowment of a species.
The haploid set of chromosomes.

genome

, genom
1. the full complement of genetic material within an organism
2. all the genes comprising a haploid set of chromosomes
References in periodicals archive ?
The shares of Human Genome Sciences (NASDAQ: HGSI) closed up 2.
Human Genome Sciences is a company with the mission to discover, develop, manufacture and market innovative drugs that serve patients with unmet medical needs, with a primary focus on protein and antibody drugs.
He and the other investigators who sequenced the mouse genome report that some 80 percent of mouse genes have a single counterpart in the human genome, while about 20 percent have multiple versions in people.
The more scientists learn about the surprisingly limited amount of information contained within the human genome itself--and its remarkable lack of diversity among individuals--the more it becomes evident how much forces other than genes determine human health.
A delightful, well-written, and scientifically accurate account of the human genome.
When we set up Human Genome Sciences, I intended to transform the pharmaceutical industry and create my own drug company.
Conserved genes from other species may be mapped to the homologous region of the human genome by comparing the PCR pattern for each cell line to reference loci with well-established map positions.
If you own shares of Human Genome and would like to learn more about these claims or if you wish to discuss these matters and have any questions concerning this announcement or your rights, contact Richard A.
The discovery of SNPs in the human genome has been aided by the development of a panel of samples known as the polymorphism discovery resource (PDR) panel proposed by the National Human Genome Research Institute (Collins et al.
Chairman and CEO, Human Genome Sciences, said, "We are pleased to enter into this agreement with Genentech.
That's comparable to the number of genes many scientists now think the human genome contains.
For the past 12 years, an international consortium has been methodically deriving the sequence of the 3 billion nucleotides that make up the human genome.

Full browser ?