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see geneticsgenetics,
scientific study of the mechanism of heredity. While Gregor Mendel first presented his findings on the statistical laws governing the transmission of certain traits from generation to generation in 1856, it was not until the discovery and detailed study of the
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the overall genetic constitution of an organism/species as constituted by the chromosomal makeup of every member (the term arises from a combination of the terms ‘gene’ and ‘chromosome’). See also GENETICS, HUMAN GENOME PROJECT.



a haploid chromosome set; the sum total of the genes localized in the individual set of chromosomes of a given organism. The term was introduced in 1920 by the German biologist H. Winkler. The genome is usually understood to mean the sum of the genes concentrated in the chromosomes, without taking into account the hereditary determinants connected with the structures of cytoplasm. In the gametes of diploid organisms, as well as in the cells of haploid organisms, there is one genome; in the somatic cells of diploid organisms there are two genomes. With an increase in ploidy of the cells, the number of genomes grows. In fertilization, the genomes of the paternal and maternal gametes unite. As a rule, genomes obtained from paternal and maternal gametes are homologous. Homology between all or some genomes exists in all but distant hybrids. Absolute homology of two genomes may be defined as the coinciding of the linear arrangement of the genes in every chromosome. This coinciding ensures the possibility of the normal conjugation of chromosomes in meiosis.

Changes in the number of chromosomes (for example, polyploidy or an increase or loss of individual chromosomes) are called genomic mutations. An organism in which one and the same genome is repeated several times is called au-topolyploid. An organism in which different genomes are combined is called allopolyploid. Wheats may serve as an example of the allopolyploids. The haploid number of chromosomes in hard wheat is 14, in soft wheat, 21; and in einkorn, seven. By hybridization and the study of the conjugation of chromosomes in meiosis, it was ascertained that in all wheats there is one common genome (genome A) made up of seven chromosomes. In hard and soft wheat there are two common genomes (genomes A, B), each having seven chromosomes. Finally, in soft wheat, there is still another special genome (genome D), also made up of seven chromosomes. Thus, the genomic formula for einkorn is AA and for hard wheat it is AABB. Soft wheat, which has arisen in the process of evolution by the crossing of three different wild cereals and by the doubling of the number of chromosomes in the hybrids, has the genomic formula AABBDD.

In the experiments of the Soviet geneticist G. D. Kar-pechenko, radish and cabbage genomes were combined for the first time in a hybrid organism. By means of corresponding crossings and cytological analysis, the origin of separate genomes can be established. For example, V. A. Rybin obtained (resynthesized) a cultivated plum by crossing the cherry plum and the sloe; thus it was established that the genome of a plum includes cherry plum and sloe genomes. Of great significance in understanding the structure and functioning of the genome have been the establishment of the structure of the molecules of nucleic acids (DNA and RNA) and of the mechanisms of their replication, and the establishment of the means of “tracing” and transmitting genetic information.



The genetic endowment of a species.
The haploid set of chromosomes.


, genom
1. the full complement of genetic material within an organism
2. all the genes comprising a haploid set of chromosomes
References in periodicals archive ?
The Human Genome Project, launched in 1990, set out to map the human genome, the 100,000 or so genes that determine the physical characteristics of human biology.
Comparative genetic mapping between the region of mouse chromosome 13 with the bg mutation and the human genome indicates homology with distal chromosome 1 q.
These candidates are distributed across all the human chromosomes except for the Y-chromosome, and altogether represent > 2% of all known human genes (International Human Genome Sequencing Consortium 2004), Efforts for the EGP have also focused on completing SNP discovery across entire pathways of interacting genes, such as the base-excision repair pathway illustrated in Figure 1.
The shares of Human Genome Sciences (NASDAQ: HGSI) closed up 2.
Francis Collins, director of the National Human Genome Research Institute in Bethesda, Md.
Despite all the hype surrounding the "completion" of the Human Genome Project, many biologists are disappointed by its results, and there is a deepening suspicion that gene sequences by themselves explain very little about why we get sick and ultimately die.
The sequencing of the human genome by the Human Genome Project and Celera is only the beginning of a revolution that many predict will transform medicine.
For certain areas of application this technology was licensed to Principia Pharmaceutical, a wholly owned subsidiary of Human Genome Sciences.
First and foremost, the Human Genome Project will revolutionize the practice of medicine, allowing doctors to possibly prevent and treat diseases caused by faulty genes--such as Huntington's disease, a nerve-cell disorder that may be the result of a single gene's mutation, or alteration.
In the December issue of Nature, the Human Genome Project published the genetic sequence of the first human chromosome to be fully mapped, chromosome 22.
The human genome is a biological map laying out the exact sequence of the estimated 3.

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