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Strong hyaluronan sales from existing products and revenue from new product development contributed to the double-digit revenue growth," said Allingham.
PEGPH20 (PEGylated recombinant human hyaluronidase) is an investigational drug administered intravenously that targets the degradation of hyaluronan (HA), a major component of the extracellular matrix.
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.
About PEGPH20 PEGPH20 is an investigational PEGylated form of Halozyme's proprietary recombinant human hyaluronidase under clinical development for the systemic treatment of tumors that accumulate hyaluronan.
The research, published in the journal Nature, showed that mole rat hyaluronan activates a powerful anti-cancer gene called p16 which prevents cells proliferating when too many of them crowd together.
The researchers were also able to identify the specific gene hyaluronan synthase 2, or HAS2, responsible for the development of HMW-HA.
Commercially available hyaluronan is either isolated from mammalian tissues or produced in cultured streptococci with average molecular weights ranging from one to six million.
After blood was drawn from all patients, they were randomized to intra-articular injections of either autologous conditioned serum (ACS), hyaluronan (HA), or saline twice a week for 3 weeks.
1) Until the late 1970s, hyaluronan was described as a "goo" molecule, a ubiquitous carbohydrate polymer that is part of the extracellular matrix.
Besides polysaccharides, they cover the other natural polymers cellulose, starch, hyaluronan, and chitin and chitosan.
But researchers funded in part by the National MS Society have discovered that hyaluronan may pose an obstacle to the body's ability to repair myelin.