Table 1: Types of epigenetic drugs: Drugs Class 5-aza-cytidine (azacitidine), Nucleoside DNMTIs 5-aza-2-deoxycytidine (decitabine), 5-fluoro-2-deoxycytidine, Zebularine RG108 Non-Nucleoside DNMTIs MG98 Antisense Oligonucleotides Table 2: HDAC inhibitors: Drugs Class Valproic acid, Aliphatic acids Sodium phenylbutyrate, Pivaloyloxymethyl butyrate, Vorinostat Romidepsin Cyclic peptides Belinostat, Hydroxamic acids
Panobinostat Entinostat, Benzamides Mocetinostat
A number of synthetic compounds including imidazoles, hydroxamic acids
, and phosphazenes are effective urease inhibitors, but limited studies have been conducted on natural products (Ahmad et al.
Colorimetric determination of organic compounds by formation of hydroxamic acids
The chemistry of hydroxamic acids
has received considerable attention [5, 6], and this interest is also connected with a variety of their pharmaceutical and industrial applications [7, 8].
are known to be highly active against fungi, bacteria, and some pests (White and Hill 1943, Neilands 1967, Weisburger and Weisburger 1973, Chatterjee 1978, Rather and Hanel 1990, Thackary et al.
can be divided into four groups: phenolic acids, hydroxamic acids
com/research/jmmgkb/the_chemistry_of_h) has announced the addition of John Wiley and Sons Ltd's new book "The Chemistry of Hydroxylamines, Oximes and Hydroxamic Acids
Poster #356 -- "In Vitro Profile of N-Alkyl Urea Hydroxamic Acids
that Inhibit Bacterial Peptide Deformylase;" Zhengyu Yuan, Ph.
Azaindole hydroxamic acids
are hiv-1 integrase inhibitors
HDAC inhibitors can be divided into four main classes: cyclic tetrapeptides (I), short-chain fatty acids (II), hydroxamic acids
(III), and benzamides (IV).
The third poster, entitled "The Design of Substituted Phenyl Hydroxamic Acids
as Inhibitors of Histone Deacetylases," outlined the design of substituted phenyl hydroxamic acids
as HDAC inhibitors.
14 Issue 1), the Company describes its recent progress in the development of HDAC inhibitors for oncology, which includes hydroxamic acids
, anilides, TSA-like straight chain derivatives, and 2-aminophenylamides of omega-substituted alkanoic acids.