(79) outlined the synthesis and evaluation of a series of succinimide hydroxamic acids
, which were prepared and evaluated for HDAC inhibition and antiproliferation.
Based on their chemical structures, HDAC inhibitors include short-chain fatty acids, hydroxamic acids
, synthetic benzamides, and cyclic peptides, which exhibit various bioactivities and specificities.
Kapoor, "Stability constants of rare earths with hydroxamic acids
," Journal of Inorganic and Nuclear Chemistry, vol.
Hackbarth, Corinne J., Dawn Z., Chen, Jason G., Lewis, Kirk C., James B., Mangold, Jeffrey A., Cramer, Peter S., Margolis, "N-alkyl urea hydroxamic acids
as a new class of peptide deformylase inhibitors with antibacterial activity" Antimicrobial agents and chemotherapy 46, 9 (2002): 2752-2764.
Hou, "Pectin hydroxamic acids
exhibit antioxidant activities in vitro," Journal of Agricultural and Food Chemistry, vol.
Allelopathic agents reported from higher plants include coumarins, flavonoids, alkaloids, tannins, certain quinones, hydroxamic acids
, sesquiterpene lactones, and various mono-, sesqui-, di-, and triterpenes, among other compounds, synthesized from either the acetate or the shikimate pathways .
Table 1: Types of epigenetic drugs: Drugs Class 5-aza-cytidine (azacitidine), Nucleoside DNMTIs 5-aza-2-deoxycytidine (decitabine), 5-fluoro-2-deoxycytidine, Zebularine RG108 Non-Nucleoside DNMTIs MG98 Antisense Oligonucleotides Table 2: HDAC inhibitors: Drugs Class Valproic acid, Aliphatic acids Sodium phenylbutyrate, Pivaloyloxymethyl butyrate, Vorinostat Romidepsin Cyclic peptides Belinostat, Hydroxamic acids
Panobinostat Entinostat, Benzamides Mocetinostat
A number of synthetic compounds including imidazoles, hydroxamic acids
, and phosphazenes are effective urease inhibitors, but limited studies have been conducted on natural products (Ahmad et al.
Kaolmaon, "Molecular layers of hydroxamic acids
in copper corrosion inhibition," Journal of Electroanalytical Chemistry, vol.582, no.1-2, pp.
WP1 shows the use of hydroxamic acids
2 as starting compounds whose oxidation is performed either with the more soluble tetraalkylammonium periodate salts or PhI[(OAc).sub.2] (path a) .
Pharmacophore model on histone deacetylase (HDAC) with known hydroxamic acids
and cyclic peptides shows four pharmacophore features: one hydrogen acceptor and one hydrophobic and two aromatic rings  and in the study with known hydroxamic acids
, benzamides, and biphenyl derivatives on HDAC  three pharmacophore features were shown: hydrogen acceptors, hydrogen donors, and hydrophobic aromatic ring.
Important secondary metabolites identified as allelochemicals are phenolics, alkaloids, flavonoids, terpenoids, momilactone, hydroxamic acids
, brassinosteroids, jasmonates, salicylates, glucosinolates, carbohydrates and amino acids (Kruse et al., 2000; Jabran and Farooq, 2012).