Hydroxylamine


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Related to Hydroxylamine: Semicarbazide

hydroxylamine

[‚hī‚dräk′sil·ə‚mēn]
(inorganic chemistry)
NH2OH A colorless, crystalline compound produced commercially by acid hydrolysis of nitroparaffins, decomposes on heating, melts at 33°C; used in organic synthesis and as a reducing agent.

Hydroxylamine

 

H2NOH, is the product of the replacement of one hydrogen atom in the ammonia molecule (NH3) by an OH group. It forms colorless acicular crystals. Density, 1,204.4 kg/m3 (at 23.5° C); melting point, 33°-34° C; boiling point, 58° C at 2.933 kilonewtons per sq m (22 mm Hg). Hydroxylamine is stable at 0° C; at 20° C it decomposes slowly. An increase in temperature accelerates the decomposition, and at 130° C it explodes.

Hydroxylamine is hygroscopic. It dissolves readily in water to form hydroxylamine hydrate, which is a weak base: NH2OH·H2O ⇆ NH3OH+ + OH. Upon reaction with acids, hydroxylamine hydrate gives hydroxyammonium salts—for example, NH3OHCl and (NH3OH)2SO4—which have strong reducing properties. Hydroxylamine dissolves readily in methyl and ethyl alcohols but is insoluble in acetone, benzene, and petroleum ether. It is oxidized by atmospheric oxygen to HNO2. Hydroxylamine sulfate is produced industrially by reducing sodium nitrite with sulfur dioxide in the presence of sodium carbonate. Free hydroxylamine is produced by distilling alkaline solutions of the salts. Hydroxylamine and its derivatives are poisonous. Salts of hydroxylamine are extensively used in the pharmaceutical industry, in making kapron, and in analytical chemistry.

REFERENCE

Brikum, I. K., M. T. Kozlovskii, and L. V. Nikitina. Gidrazin igidroksilamin i ikh primenenie v analiticheskoi khimii. Alma-Ata, 1967.

V. S. LAPIK

References in periodicals archive ?
At a basic level, some models invoke, for example, a physical protection of organic matter as a function of clay content, but to our knowledge, no model explicitly accounts for thermal decomposition of hydroxylamine or the catalysis of reactions by metal species, although DNDC purportedly tracks oxidation-reduction reactions over a range of potentials.
05 mM), hydroxylamine (200 mM) and EDTA (200 mM), 150 l of essential oil (1 mg/ml) in methanol in various concentrations and 750 l phosphate buffer solution (pH = 7.
Hydroxylamine is used as an irreversible inhibitor of the OEC (BULYCHEV; VREDENBERG, 2001), it inhibits the donation of electrons to [P.
The phthalimido-protected BODIPY was converted to the hydroxylamine derivative using hydrazine with phthalimide as the leaving group (Figure 24).
Our one of such interest involves the use of poly-p- aminophenol coated electrodes that have been used for the production of hydroxylamine [3].
However, hydroxylamine, which is known as a toxic intermediate metabolite and formed by N-hydroxylation may resulted in hemolytic anemia, and DHS.
To the synaptosomal fractions, 1 ml of alkaline hydroxylamine hydrochloride followed by 1 ml of 50% HCl was added.
The testing objects were divided into a control and a UVA irradiation group, and then we detected the proliferation capacity with methylthiazdyl tetrazolium (MTT) and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, content of maleic dialdehyde (MDA) with hydroxylamine, colorimetric, thiobarbituric acid (TBA) methods.
Syngenta Ltd, express hazardous substance consent for the storage and use of hydroxylamine sulphate, Syngenta Ltd, Leeds Road.
T] showed resistance to isoniazid, thiophene-2carboxylic hydrazide, hydroxylamine, thiacetazone, and picrate.
Briefly, it consists of reacting the ester with hydroxylamine to produce a hydroxamic acid, which can be treated with a Iron(III) solution, producing a chromophore if esters are present with an absorption maxima around 505-520nm.
Ten percent hydroxylamine was added and the samples were heated to 60 C in a dry heat block for 30 min to complete the oxime derivatization.