Hyperkeratosis

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Related to Hyperkeratinization: keratosis pilaris

hyperkeratosis

[¦hī·pər·ker·ə′tō·səs]

(medicine)

Hypertrophy of the cornea.

Hypertrophy of the horny layer of the skin.

Hyperkeratosis

excessive development of the corneous layer of the skin in humans. Hyperkeratosis may be caused by external factors (such as prolonged pressure, friction, or the effects of lubricating oils) or internal factors (endocrine dysfunctions, hypovitaminosis A, occupational intoxication). Hyperkeratosis is manifested by the formation of horny plates, nodes of various sizes, protuberances, and spurs; the skin becomes dry and perspiration decreases. Hyperkeratosis may be accompanied by the formation of painful cracks (on the palms and soles). It may be limited (calluses, warts, keratomas) or diffuse, spread over large areas or the entire skin surface (ichthyosis). Treatment consists in soda or soap baths, vitamin therapy, and medications that dissolve the horny substance.

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References in periodicals archive ?

Hyperkeratinization, identified in three cases, might indicate chronicity of the allergic skin disease (IHRKE, 2009).

A retrospective study of canine cutaneous food allergy at a Veterinary Teaching Hospital from Jaboticabal, Sao Paulo, Brazil/Estudo retrospectivo da dermatite trofoalergica canina em um Hospital Veterinario de Jaboticabal, Sao Paulo, Brasil

These anatomic abnormalities are thought to be caused by the hyperkeratinization of the follicular infundibulum, which can lead to dilatation and rupture and release of bacteria within the dermis (40).

Bacterial pathogens associated with Hidradenitis Suppurativa, France

Compared with haired mice, hairless mouse strains (hr/hr mutants) are very sensitive to TCDD-induced lesions characteristic of chloracne, including epidermal hyperplasia and hyperkeratinization and involution of the sebaceous glands (Puhvel and Sakamoto 1988).

Effects of in utero exposure of C57bl/6J mice to 2,3,7,8-tetrachlorodibenzop-dioxin on epidermal permeability barrier development and function

1] The precise mechanisms of the acne process is known to be characterized by sebum overproduction, follicular hyperkeratinization, oxidative stress and inflammation.

A study of changes in lipid profile in obese and non-obese females with acne vulgaris

Various theories postulate eccrine ductal blockage without damage to sweat ducts,16 hyperkeratinization and obstruction of eccrine sweat duct,17 blockage of neuroglandular transmission and inhibition of secretory mechanism at cellular level.

Efficacy and safety of tap water iontophoresis for palmoplantar hyperhidrosis

It is caused by an association of four key factors: increased sebum production, follicular hyperkeratinization, colonization with the bacteria Propionibacterium acnes and production of inflammation.

KLOX Technologies to Meet with Leaders in Acne During the American Academy of Dermatology Annual Meeting in Miami

28) Expression of filaggrin is enhanced in conditions of hyperkeratinization and thus serve as useful markers to distinguish non-keratinized from keratinized epithelia.

Keratinization and its disorders

Hyperkeratosis or hyperkeratinization (also known as retention hyperkeratosis) is a crucial event in the development of acne lesions, but the pathogenesis remains unclear.

Acne life cycle: the spectrum of pediatric disease

There was also sparse singlecell hyperkeratinization.

Epidermoid carcinoma involving the parotid gland and orbital region: case report of a rare entity

Any person showing pigmentary changes, such as hyperpigmentation (melanosis) or hypopigmentation (leucomelanosis) and/or hyperkeratinization (keratosis), with or without other manifestations of chronic arsenic toxicity and having a history of arsenic exposure through water for more than six months, was diagnosed as an 'arsenicosis' case.

Prevalence of arsenicosis in Terai, Nepal

Increases of this hormone are believed to promote acne via hyperkeratinization, he said.