Hyperkeratosis

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Related to Hyperkeratinization: keratosis pilaris

hyperkeratosis

[¦hī·pər·ker·ə′tō·səs]
(medicine)
Hypertrophy of the cornea.
Hypertrophy of the horny layer of the skin.

Hyperkeratosis

 

excessive development of the corneous layer of the skin in humans. Hyperkeratosis may be caused by external factors (such as prolonged pressure, friction, or the effects of lubricating oils) or internal factors (endocrine dysfunctions, hypovitaminosis A, occupational intoxication). Hyperkeratosis is manifested by the formation of horny plates, nodes of various sizes, protuberances, and spurs; the skin becomes dry and perspiration decreases. Hyperkeratosis may be accompanied by the formation of painful cracks (on the palms and soles). It may be limited (calluses, warts, keratomas) or diffuse, spread over large areas or the entire skin surface (ichthyosis). Treatment consists in soda or soap baths, vitamin therapy, and medications that dissolve the horny substance.

References in periodicals archive ?
These anatomic abnormalities are thought to be caused by the hyperkeratinization of the follicular infundibulum, which can lead to dilatation and rupture and release of bacteria within the dermis (40).
Compared with haired mice, hairless mouse strains (hr/hr mutants) are very sensitive to TCDD-induced lesions characteristic of chloracne, including epidermal hyperplasia and hyperkeratinization and involution of the sebaceous glands (Puhvel and Sakamoto 1988).
1] The precise mechanisms of the acne process is known to be characterized by sebum overproduction, follicular hyperkeratinization, oxidative stress and inflammation.
Various theories postulate eccrine ductal blockage without damage to sweat ducts,16 hyperkeratinization and obstruction of eccrine sweat duct,17 blockage of neuroglandular transmission and inhibition of secretory mechanism at cellular level.
It is caused by an association of four key factors: increased sebum production, follicular hyperkeratinization, colonization with the bacteria Propionibacterium acnes and production of inflammation.
28) Expression of filaggrin is enhanced in conditions of hyperkeratinization and thus serve as useful markers to distinguish non-keratinized from keratinized epithelia.
Hyperkeratosis or hyperkeratinization (also known as retention hyperkeratosis) is a crucial event in the development of acne lesions, but the pathogenesis remains unclear.
Any person showing pigmentary changes, such as hyperpigmentation (melanosis) or hypopigmentation (leucomelanosis) and/or hyperkeratinization (keratosis), with or without other manifestations of chronic arsenic toxicity and having a history of arsenic exposure through water for more than six months, was diagnosed as an 'arsenicosis' case.
Increases of this hormone are believed to promote acne via hyperkeratinization, he said.