Also found in: Dictionary, Medical, Acronyms, Wikipedia.


Hypertrophy of the cornea.
Hypertrophy of the horny layer of the skin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



excessive development of the corneous layer of the skin in humans. Hyperkeratosis may be caused by external factors (such as prolonged pressure, friction, or the effects of lubricating oils) or internal factors (endocrine dysfunctions, hypovitaminosis A, occupational intoxication). Hyperkeratosis is manifested by the formation of horny plates, nodes of various sizes, protuberances, and spurs; the skin becomes dry and perspiration decreases. Hyperkeratosis may be accompanied by the formation of painful cracks (on the palms and soles). It may be limited (calluses, warts, keratomas) or diffuse, spread over large areas or the entire skin surface (ichthyosis). Treatment consists in soda or soap baths, vitamin therapy, and medications that dissolve the horny substance.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Microscopically, the squamous papillae are of variable lengths and shapes, lined by irregular well-differentiated squamous epithelium with overlying hyperkeratosis (Figure 5, A).
Light microscopic image of the lesion showing hyperkeratosis on the surface, thickening of the granular layer, and marked psoriasiform hyperplasia (hematoxylin-eosin staining, x40).
On the other hand, there are reports showing that subungual hyperkeratosis is the most common feature [13].
Hyperkeratosis indicates large number of anucleated squamous cells present in Pap smear.
Records of milk yield, mastitis occurrence and hyperkeratosis of 453 Holstein cows (with 1812 teats) from a large herd with calving dates from December 2012 to December 2014 in Qazvin province of Iran were used in this study.
Efforts to control the progression of upper aerodigestive hyperkeratosis and dysplasia with medication have been ineffective.
Due to the fact that cutaneous nodules, either ulcerated or not, and generalized footpad hyperkeratosis accompanied by depigmentation and erosion were the main constituents of the cutaneous disease in this dog and its many clinical similarities to canine leishmaniosis (Leishmania infantum/chagasi) [12, 20], made its exclusion with the aid of serology and cytology a diagnostic priority.
Hyperkeratosis may appear on the knees, hands, buttocks, elbows, and axillae.
Histologic evidence of hyperkeratosis on biopsy in the context of characteristic clinical signs confirms the diagnosis.
A skin biopsy taken from the arm showed epidermal hyperkeratosis, focal parakeratosis, exocytosis, diffuse lysis of the basal layer, band-like lymphocytic infiltration of the dermis, lymphocytic infiltrate around the hair follicle, and scattered melanin incontinence (Figure-2a).
About 10 of 1,100 tested properties in the past and 2 properties currently have soil arsenic levels of potential public health for children for noncancerous dermal health effects (e.g., hyperpigmentation and hyperkeratosis).
Iain B McIntosh discusses the advantages, or otherwise, of foot orthotics (see page 4) and we have part 2 of Hyperkeratosis of the foot written by Julia Potter, Senior Lecturer, School of Health Sciences, University of Southampton.