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Hypertrophy of the cornea.
Hypertrophy of the horny layer of the skin.



excessive development of the corneous layer of the skin in humans. Hyperkeratosis may be caused by external factors (such as prolonged pressure, friction, or the effects of lubricating oils) or internal factors (endocrine dysfunctions, hypovitaminosis A, occupational intoxication). Hyperkeratosis is manifested by the formation of horny plates, nodes of various sizes, protuberances, and spurs; the skin becomes dry and perspiration decreases. Hyperkeratosis may be accompanied by the formation of painful cracks (on the palms and soles). It may be limited (calluses, warts, keratomas) or diffuse, spread over large areas or the entire skin surface (ichthyosis). Treatment consists in soda or soap baths, vitamin therapy, and medications that dissolve the horny substance.

References in periodicals archive ?
With regard to dermal effects, increased OGG1 expression showed increased risk of skin hyperkeratosis in males, but the trend was not statistically significant in females.
The purpose of the present study was twofold: (1) to identify common characteristics or predisposing factors in patients with hyperkeratosis, and (2) to determine the clinical significance and appropriate follow-up of hyperkeratosis when it appears as the sole diagnosis on the Papanicolaou smear.
Cross sections of the tarsi showed moderate to severe orthokeratotic hyperkeratosis, in some cases associated with Knemidocoptes species-like mites.
From these observations, it may be added that besides the size of amyloid deposition, prominent hyperkeratosis, acanthosis and papillomatosis, other features like increased basal layer pigmentation and pigment incontinence (both more frequent in macular amyloidosis) as well as papillomatosis and periappendageal mononuclear and neutrophilic dermal infiltrate (more frequent in lichen amyloidosis) can be used for distinction between the two histologically.
The dermatological lesions appear first between the ages of 1 to 4 years and include palmoplantar keratosis, varying from mild psoriasiform scaly skin to overt hyperkeratosis.
All of our healed grafts fared well as none of them developed marginal hyperkeratosis for which non glabrous skin grafts are notorious and we had no incidence of graft contracture or subdermal fibrosis.
Hyperkeratosis indicates large number of anucleated squamous cells present in Pap smear.
Other skin lesions included footpad hyperkeratosis, crusting, depigmentation, and erosions (Figure 2).
Other findings included hyperkeratosis on the buccal, labial, and palatal mucosa, which created a thickened and nodular appearance.