Microscopically, the squamous papillae are of variable lengths and shapes, lined by irregular well-differentiated squamous epithelium with overlying hyperkeratosis
(Figure 5, A).
Light microscopic image of the lesion showing hyperkeratosis
on the surface, thickening of the granular layer, and marked psoriasiform hyperplasia (hematoxylin-eosin staining, x40).
On the other hand, there are reports showing that subungual hyperkeratosis
is the most common feature .
indicates large number of anucleated squamous cells present in Pap smear.
Records of milk yield, mastitis occurrence and hyperkeratosis
of 453 Holstein cows (with 1812 teats) from a large herd with calving dates from December 2012 to December 2014 in Qazvin province of Iran were used in this study.
Efforts to control the progression of upper aerodigestive hyperkeratosis
and dysplasia with medication have been ineffective.
Due to the fact that cutaneous nodules, either ulcerated or not, and generalized footpad hyperkeratosis
accompanied by depigmentation and erosion were the main constituents of the cutaneous disease in this dog and its many clinical similarities to canine leishmaniosis (Leishmania infantum/chagasi) [12, 20], made its exclusion with the aid of serology and cytology a diagnostic priority.
may appear on the knees, hands, buttocks, elbows, and axillae.
Histologic evidence of hyperkeratosis
on biopsy in the context of characteristic clinical signs confirms the diagnosis.
A skin biopsy taken from the arm showed epidermal hyperkeratosis
, focal parakeratosis, exocytosis, diffuse lysis of the basal layer, band-like lymphocytic infiltration of the dermis, lymphocytic infiltrate around the hair follicle, and scattered melanin incontinence (Figure-2a).
About 10 of 1,100 tested properties in the past and 2 properties currently have soil arsenic levels of potential public health for children for noncancerous dermal health effects (e.g., hyperpigmentation and hyperkeratosis
Iain B McIntosh discusses the advantages, or otherwise, of foot orthotics (see page 4) and we have part 2 of Hyperkeratosis
of the foot written by Julia Potter, Senior Lecturer, School of Health Sciences, University of Southampton.