Phenotypically guided filtering of the index patient's WES data left a single heterozygous, predicted detrimental single-nucleotide variant in SOX5, a gene previously linked to the phenotypes hyperkinesia
The asynchronous paroxysms C-like position ((a) and (c)) and screw-like hyperkinesia
((b) and (d)) were observed for both sertraline concentrations.
 in terms of, for example, the presence of pyramidal signs, extrapyramidal hyperkinesia
, and ataxia were observed in 5 CCFDN patients from our group.
In conclusion, our results obviously show that administration of mitragynine is able to produce an antidepressant-like effect in FST and TST, which not due to effect of psycho-stimulant or hyperkinesia
. Besides, we provide convincing evidence that the effect is due to interaction with neuroendocrine HPA axis systems.
Participants receiving risperidone experienced extrapyramidal symptoms--dystonia, hyperkinesia
, tremor, or abnormal gait--to a greater degree than did placebo patients.
*** Examples of hyperkinesia
include akathisia (restlessness) and tremor.
In the hot and crowded conditions of raves, mild versions of the serotonin syndrome often develop, when hyperthermia, mental confusion, and hyperkinesia
(10) They cited several clinical features that are highly suggestive of a malignant etiology: (1) single-branch palsy, (2) slow progression beyond 3 weeks, (3) no return of function at 6 months, (4) facial hyperkinesia
, especially hemifacial spasm, (5) associated cranial neuropathies, (6) recurrent ipsilateral paralysis, and (7) pain; some of these features were seen in our case.
Factor 1 consisted of items relating to 'inhibition' of both the behavioural and emotional aspects such as restlessness and hyperkinesia
, euphoria, inability to inhibit responses, lack of concern, disinhibition, and temporal sequencing problems.
By using stereotactic image-guided techniques, targets can be chosen to treat different symptoms: the ventrointermediate nucleus of thalamus for tremor; the internal globus pallidus for dyskinesia, dystonia, rigidity, akinesia, and tremor; and the subthalamic nucleus for all cardinal symptoms in advanced Parkinson's disease, including drug-induced hyperkinesia
(secondary to reduced drugs).
The child tolerated only a very gradual increase of medication, complicated by dose-dependent side effects, mainly hyperkinesia
Spectrum of behavioural problem seen was hyperkinesia