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fibrous connective tissueconnective tissue,
supportive tissue widely distributed in the body, characterized by large amounts of intercellular substance and relatively few cells. The intercellular material, or matrix, is produced by the cells and gives the tissue its particular character.
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 that forms at the site of injury or disease in any tissue of the body. Scar tissue may replace injured skin and underlying muscle, damaged heart muscle, or diseased areas of internal organs such as the liver. Dense and thick, it is usually paler than the surrounding tissue because it is poorly supplied with blood, and although it structurally replaces destroyed tissue, it cannot perform the functions of the missing tissue. Scar tissue may therefore limit the range of muscle movement or prevent proper circulation of fluids when affecting the lymphatic or circulatory system. Extensively scarred tissue may lose its ability to function normally.
The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



the end result of the development of connective tissue at the site of the healing of a wound or ulcer. The timely surgical treatment of an incised wound with smooth margins leaves a soft and sometimes barely noticeable linear scar. Large wounds that suppurate and heal by second intention form granulations and subsequently epithelize, resulting in the formation of broad scars that are attached to underlying tissues.

Excessive scar tissue that is elevated above the skin surface is called a keloid. Extensive scars formed after burns or the prolonged healing of suppurative wounds in the area of extremity joints or on the neck result in a limitation of mobility, or contracture; these scars require plastic surgery. Scars that develop after the healing of gastric or duodenal ulcers often lead to the deformation of the stomach and duodenum, the disruption of evacuation from the stomach, and the development of pyloric stenosis.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


A steep, rocky eminence, such as a cliff or precipice, where bare rock is well exposed. Also known as scaur; scaw.
A permanent mark on the skin or other tissue, formed from connective-tissue replacement of tissue destroyed by a wound or disease process.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


1. any mark left on the skin or other tissue following the healing of a wound
2. the mark on a plant indicating the former point of attachment of a part, esp the attachment of a leaf to a stem


1. an irregular enlongated trench-like feature on a land surface that often exposes bedrock
2. a similar formation in a river or sea
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
Hypertrophic scars form as a result of aberrations in physiologic wound healing and may arise following any insult to the deep dermis.
Intralesional interferon gamma treatment for keloids and hypertrophic scars. Arch Otolaryngol Head Neck Surg 1990;116(10):1159-62.
Morphometric analysis of eukaryotic initiation factor 6 in hypertrophic scar and normal skin tissues
Distinguishing between keloids and hypertrophic scars can be challenging, because both types of scars arise histologically from excessive collagen buildup during the wound healing process.
KEYWORDS: Hypertrophic Scar, Fibroblast Cell, Lipopolysaccharide, Mitogen-Activated Protein Kinase.
Post-operative surgical scars such as keloids and hypertrophic scars (HS) generally occur among persons with abnormal wound healing.1 Hypertrophic scars are usually characterized by the presence of inflammation, excess fibroblast proliferation, and abnormal deposition of extracellular matrix proteins.2 Cesarean section (CS) is one of the most common major surgical interventions carried out on the female population and postoperative scar development is not rare after the procedure.
Portable ultraviolet light A1 light source to treat hypertrophic scar. Dermatologica Sinica.
The efficacy of combined herbal extracts gel preparation in the prevention of postsurgical hypertrophic scar formation.
Additionally, fibroblasts were observed to synthesize proteins involved in continuous TGF-[beta] signal transduction in both hypertrophic scars and keloids (20-24).
One girl of African descent had a hypertrophic scar (from a linear closure).
(2015) prepared rabbit ear hypertrophic scar models by full thickness skin excisions of various sizes, mostly circular in shape, on ventral surface of rabbit ears.