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Condition caused by insufficient secretion of pituitary hormones, especially of the adenohypophysis. Also known as panhypopituitarism.



a chronic condition caused by reduced internal secretion of the pituitary body.

Hypopituitarism is manifested by insufficiency of function of the thyroid, adrenal cortex, and gonads. Trauma, tumors, infections, and hemorrhages in the area of the base of the brain can result in hypopituitarism. Hypopituitarism is manifested in arrested growth (nanism), impairment of lipometabolism, causing obesity or severe emaciation (cachexia), or underdevelopment of the sexual organs. In women with hypopituitarism, menstruation ceases and the uterus, ovaries, and mammary glands atrophy. In men the testicles and penis atrophy. Physical and mental languor, frequent dizziness, buzzing in the ears, headaches, sleepiness, susceptibility to fatigue, and a lowering of the basal metabolism are characteristic of hypopituitarism. Pituitary tumors are treated by X-ray and radiotherapy or surgical operation; other forms are treated by hormonal therapy.


References in periodicals archive ?
Agenesis of internal carotid artery associated with congenital anterior hypopituitarism.
Current treatment options for patients suffering from hypopituitarism, a dysfunction of the pituitary gland, are far from optimal.
The current treatment options for patients suffering from hypopituitarism, a dysfunction of the pituitary gland, are far from optimal," says first study author Bastian Zimmer of the Sloan Kettering Institute for Cancer Research.
The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature.
Within the risks reported are hypothalamic damage, visual impairment, and endocrine complications, which range between 45 and 90%, with associated manifestations such as anterior hypopituitarism, insipid diabetes, growth alterations, and feeding and behavioural abnormalities [5].
Regarding the group with a defined diagnosis, androgen receptor defects (n = 25), 5[alpha]-reductase type 2 deficiency (n = 20), and hypogonadotropic hypogonadism (n = 12), including six with associated hypopituitarism, were found with higher frequencies, followed by the group of defects in testosterone synthesis that included one patient with HSD3B2 deficiency, one with CYP17A1 deficiency, and two with HSD17B3 deficiency.
GlobalData's clinical trial report, "Hypopituitarism Global Clinical Trials Review, H2, 2015" provides an overview of Hypopituitarism clinical trials scenario.
Partial hypopituitarism following septic peritonitis with shock.
As a result of the mechanical compression to the pituitary gland or disruption of the pituitary stalk, hypopituitarism can occur and corticotrophin insufficiency is commonly observed after TBI (Agha et al.
Endocrinologists dealing with adult patients who survived cancer during childhood should ensure that they have an adequate understanding of the elevated risk that such patients are at for various endocrine conditions, such as hypogonadism, hypopituitarism, and ovarian failure.
These symptoms often do not draw attention to the diagnosis of prolactinoma highly effective role, in many cases, as long as blurred vision, headaches and hypopituitarism caused the delay.