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Related to Hypothalamic dysfunction: hypothalamus, pituitary dysfunction


Condition caused by insufficient secretion of pituitary hormones, especially of the adenohypophysis. Also known as panhypopituitarism.



a chronic condition caused by reduced internal secretion of the pituitary body.

Hypopituitarism is manifested by insufficiency of function of the thyroid, adrenal cortex, and gonads. Trauma, tumors, infections, and hemorrhages in the area of the base of the brain can result in hypopituitarism. Hypopituitarism is manifested in arrested growth (nanism), impairment of lipometabolism, causing obesity or severe emaciation (cachexia), or underdevelopment of the sexual organs. In women with hypopituitarism, menstruation ceases and the uterus, ovaries, and mammary glands atrophy. In men the testicles and penis atrophy. Physical and mental languor, frequent dizziness, buzzing in the ears, headaches, sleepiness, susceptibility to fatigue, and a lowering of the basal metabolism are characteristic of hypopituitarism. Pituitary tumors are treated by X-ray and radiotherapy or surgical operation; other forms are treated by hormonal therapy.


References in periodicals archive ?
Hypothalamic dysfunction is believed to be a source of some features of PWS, such as short stature and hypogonadism (Wattendorf & Muenke, 2005).
Hypothalamic dysfunction also is suspected as a cause of daytime sleepiness (Wagner & Berry, 2007).
Secondary to their hypothalamic dysfunction, children with PWS have been found to have functional growth hormone deficiencies (Ritzen et al.
and hypothalamic dysfunction as common denominators in these syndromes.
As energy stores are depleted, hypothalamic dysfunction occurs early on, resulting in the disordered sleep, autonomic dysfunction, low body temperatures, and hormonal dysfunctions commonly seen in these syndromes.
Dad of: Luca, six, who has Rapidonset Obesity with Hypothalamic dysfunction, Hypoventilation Autonomic Dysregulation (ROHHAD).
1), (2) Research suggests that mitochondrial and hypothalamic dysfunction are common denominators in these syndromes.
Anything that results in inadequate energy production or energy needs greater than the body's production ability can trigger hypothalamic dysfunction.