Lesch-Nyhan syndrome
(redirected from Hypoxanthine phosphoribosyltransferse (HPRT) deficiency)Also found in: Medical.
Lesch-Nyhan syndrome
[′lesh ′nī‚han ‚sin‚drōm] (medicine)
A hereditary disease of male children, transmitted as an X-linked recessive, characterized by hyperuricemia, deficiency of hypoxanthine-guanine phosphoribosyl transferase, mental retardation, spastic cerebral palsy, choreathetosis, and self-mutilating biting.