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Table-2: Percent inhibition at 0.5 mM and IC50 values of active derivatives for [alpha]-glucosidase.
(15) found the IC50 dose of curcumin on Ho-8910 cell line as 40 [micro]M.
Cytotoxic results were obtained as their concentration responsible for 50% growth retardation (IC50).
The IC50 concentration was found as 0.01 mg/mL in C-4 I cells.
Methanolic extract showed cytotoxic activity to T47D, HepG2 and C26 cells with IC50 value were 172, 360, and 330 mg/ml .
Therefore, 20 [micro]M CDDP and 750 [micro]M LIPO concentration applied for 48 hours was designated as the IC50. Treatment with LIPO or CDDP induced a dose-dependent (CDDP, IC50=20 and 50 [micro]M; LIPO IC50=750 and 1000 [micro]M) and time-dependent (48 h) inhibition of cell proliferation.
Each well was washed with PBS solution, and MKN-45 cells were exposed to Ti[O.sub.2] nanoparticles (at the IC50 value) and moved to an incubator for 48 hours.
Table 2 shows the percentage of the scavenging activity of GSE ranging from 24.8 to 55.7% with IC50 at 0.1 mg/mL.
It was noted however that the potencies of activity of the isolated compound piperine (IC50 : 59 and 111.5 [micro]M for K1 and 3D7, respectively) were relatively low compared with the crude ethanolic extract in both clones.
To determine the IC50s, 0-2500 [micro]M of bile acid was used with 0.65 [micro]M [[sup.3]H]TC.
The IC50 values were calculated from the percentage of cytotoxicity by nonlinear curve fitting and are presented in Table 3.
The 50% inhibitory concentration (IC50) was also determined for the extracts that varied from 0.014+- 0.001 (W.
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