IC50


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IC50

[¦ī¦sē ′fif·tē]
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Table-2: Percent inhibition at 0.5 mM and IC50 values of active derivatives for [alpha]-glucosidase.
(15) found the IC50 dose of curcumin on Ho-8910 cell line as 40 [micro]M.
Cytotoxic results were obtained as their concentration responsible for 50% growth retardation (IC50).
Methanolic extract showed cytotoxic activity to T47D, HepG2 and C26 cells with IC50 value were 172, 360, and 330 mg/ml .
Therefore, 20 [micro]M CDDP and 750 [micro]M LIPO concentration applied for 48 hours was designated as the IC50. Treatment with LIPO or CDDP induced a dose-dependent (CDDP, IC50=20 and 50 [micro]M; LIPO IC50=750 and 1000 [micro]M) and time-dependent (48 h) inhibition of cell proliferation.
Each well was washed with PBS solution, and MKN-45 cells were exposed to Ti[O.sub.2] nanoparticles (at the IC50 value) and moved to an incubator for 48 hours.
Table 2 shows the percentage of the scavenging activity of GSE ranging from 24.8 to 55.7% with IC50 at 0.1 mg/mL.
It was noted however that the potencies of activity of the isolated compound piperine (IC50 : 59 and 111.5 [micro]M for K1 and 3D7, respectively) were relatively low compared with the crude ethanolic extract in both clones.
The IC50 values were calculated from the percentage of cytotoxicity by nonlinear curve fitting and are presented in Table 3.
The 50% inhibitory concentration (IC50) was also determined for the extracts that varied from 0.014+- 0.001 (W.