Recently, 2 novel biomarkers, IGFBP7
and TIMP-2, were validated in a large-scale trial.
His study conclusions allow positioning the IGFBP7
as a specific proliferation and differentiation regulatory gene of keratinocytes, suggesting a therapeutic potential for this protein in papulo-squamous diseases such as psoriasis.
Although several molecules such as NGAL, KIM-1, IL-18, L-FABP, IL-6, [alpha]/I GST, NAG, IGFBP7
, and TIMP-2 have been reported to have a role in the diagnosis of AKI, none has been put into clinical use due to their specific deficiencies and problems particularly concerning their measurement method.1,3,8 Therefore, there is an ongoing search for a sensitive, specific, reliable, easy-to-measure, and cost-effective marker for the early diagnosis of AKI.
While SCr is a filtration function marker, the new test measures the TIMP2 and IGFBP7
proteins that are upregulated in response to cellular/tissue injury.
A total of seven significant SNPs were found within six candidate genes signal peptide, CUB domain, EGF-like 3 (SCUBE3), kinase insert domain receptor (KDR), tryptophan 2,3-dioxygenase (TDO), insulin-like growth factor binding protein 7 (IGFBP7
), ADAM metallopeptidase with thrombospondin type 1 motif, 3 (ADAMTS3), and alpha-fetoprotein (AFP).
Those markers include HMGA1 and 2, CD163, ApoD, tenascin, S100A6, MMP2 and 11, IGFBP7
, cathepsin K, and D2-40.
Moreover, CAV1, CD200R1, HRASLS2, MIA, TNFRSF17, CXCR3, AQP3, CCR9, IFNAR1, and CEACAM1 among the top twenty upregulated genes as well as EIF1AY, DDX3Y UTY, IL7R, IGFBP7
, and GNLY among the top twenty downregulated genes are involved in immune function of organism, while other genes function in immune responses was not clearly identified.
Cluster 7 included genes related to cell cycle (CCNG1; ERCC1) and cellular growth (IGFBP4; IGFBP7
Urinary Biomarkers TIMP-2 and IGFBP7
Early predict acute kidney injury after major surgery.
NephroCheck identifies the presence of insulin-like growth-factor binding protein 7 (IGFBP7
) and tissue inhibitor of metalloproteinases (TIMP-2) in the urine, which are related to acute kidney injury.