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Deposition of amyloid in one or more organs of the body.



or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.


References in periodicals archive ?
The Phase 1/2 study is designed to evaluate safety and preliminary indications of efficacy of ABO-101 in subjects suffering from MPS IIIB.
The AO external fixator is used popularly for the management of gustilo type IIIA and IIIB fractures.
Although PCAA informed all the airlines in advance to train their pilots to ensure that respective aircrafts are capable of using ILS CAT IIIB effectively, but some private airlines could not manage to train their crew in time so that they could land in foggy conditions, Fariha mentioned.
On the other hand, Air India is blaming the Directorate General Civil Aviation ( DGCA) for not giving CAT IIIB certificate to Dreamliner aircraft.
Another new Bobcat product will be the E85 8 tonne excavator, powered by a Yanmar 4TNV98C-VDB8 Stage IIIB compliant diesel engine providing 44.
The classification of Abu Dhabi International as CAT IIIB compliant demonstrates our commitment to offering safe and convenient travel experiences.
The ceramic transition from Late Helladic (LH) IIIB to LH IIIC has been the subject of much discussion.
The APaNGO project was approved under the INTERREG IIIB North West Europe (NWE) programme.
7 million contract for production of the fiscal year 2002 Standard Missile-2 (SM-2) Block III and IIIA All-Up-Rounds (AUR), Block IIIB (AUR), Block IIIB ORDALT kits, AN/DKT-71A Telemetric Data Transmitting Sets (TDTS), and section-level spares.
Section IIIB is mostly unique to MMC, but some information is not highly specific.
BMN250, an investigational enzyme replacement therapy using a novel fusion of recombinant human alpha-N-acetylglucosaminidase (NAGLU) with a peptide derived from insulin-like growth factor 2, is being developed for the treatment of Sanfilippo B syndrome or mucopolysaccharidosis IIIB (MPS IIIB).