Indeed, our results have demonstrated that the frequency of subjects with detectable levels of IL-13
in aspirin-administrated patients was significantly higher as compared with patients who did not receive aspirin.
MSSM-002 down-regulated inflammatory cytokines, including IL-4, IL-5, and IL-13
, all involved in chronic asthma.
T cells, there was also an increase in IL-13
GATA-3 is a transcription factor that controls expression of IL-4, IL-5, and IL-13
To induce M2-polarized THP-1 macrophages, THP-1 macrophages differentiated by the above methods were cultured with 1L-4 (25 ng/ml) and IL-13
(25 ng/ml) for 24 h, and the differentiated M2 macrophages were then washed twice with Dulbecco's phosphate buffered saline (PBS) (pH 7.
Rothenberg's lab years ago identified IL-13
as a key molecular contributor to the allergic reaction process in EoE.
Our objective was to examine the regulatory effect of IL-4 and IL-13
on IL-17 production, thus revealing the possible mechanism of how IL-4 can regulate the production of pro-inflammatory cytokines.
receptor signalling pathway hits a serious role in allergic airway disease.
The lack of targeted immune therapies other than TNF-a inhibitors in Psoriasis signals opportunities for drug developers to bring agents to market that offer treatment alternatives (Anti-IL-17, IL-13
, JAK, PDE4 inhibitors, etc).
No differences were observed in the levels of the anti-inflammatory cytokines TGF-[beta] and IL-13
in the groups (Figure 2).
These include omalizumab (an anti-IgE antibody), mepolizumab (an anti-IL5 monoclonal antibody), lebrikizumab (an IL-13
antibody) and the most recently studied subcutaneously administered dupilumab (an antibody to the alpha subunit of the IL-4 receptor), which inhibits signalling by both IL-4 and IL-13
In mice, exogenous administration of IL-13
to the lungs results in AHR, and IL-13
-blocking reagents inhibit allergen-induced AHR (Grunig et al.