RLF

(redirected from INSL3)
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RLF

Reuse Library Framework of the DoD.
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References in periodicals archive ?
Testicular descent: INSL3, testosterone, genes and the intrauterine milieu.
Mutations in INSL3 and RXFP2 genes in cryptorchid boys.
The INSL3 knockout mouse model has intra-abdominal testes and spontaneous testicular torsion, with the risk being higher in adolescent mice.
The binding of INSL3 with a specific receptor, together with testosterone, is the trigger that causes the testes to descend from inside the abdomen, where they developed during gestation, to the scrotum outside the body," explains Ren-Shan Ge, a biologist in the Hardy lab and author on the recent study.
INSL3, a Leydig cell hormone that drives development of the gubernaculum, may underlie phthalate-induced cryptorchidism (Johnson et al.
INSL3 interacts with a receptor called LGR8 and has been shown to be critical to testicular descent, while RLN3 interacts with a related receptor called LGR7, which has been implicated in mammary gland and nipple development.
In the case of the INSL3 ancestor, the duplication fluke occurred sometime before the monotremes, marsupials and placental mammals split, but after fish and frogs became separate groups.
The aim of the present study was to determine whether in utero PFOS levels are associated with altered Leydig cell function, as indicated by steroid hormone and INSL3 concentrations in amniotic fluid, and to evaluate whether these potential effects on hormone levels were associated with genital malformation in offspring.
Defects in developmental genes such as INSL3 (insulinlike factor 3) seem to be involved in some cases (Adham and Agoulnik 2004).