Imidazole


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imidazole

[‚im·ə′da‚zōl]
(organic chemistry)
C3H4N2 One of a group of organic heterocyclic compounds containing a five-membered diunsaturated ring with two nonadjacent nitrogen atoms as part of the ring; the particular compound imidazole is a member of the group.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Imidazole

 

(glyoxaline, 1,3-diazole) a heterocyclic base. Colorless crystals; boiling point, 256°C. Imidazole is readily soluble i n water and alcohol and moderately soluble in ether. It is aromatic, that is, readily undergoes halogenation, nitration, and sulfonation. The hydrogen of the NH group can be replaced by alkyl by the action of, for example, dimethylsulfate. Imidazole is prepared by reacting glyoxalwith ammonia and formaldehyde. Its derivatives (histamin, histidine, carnosine, pilocarpine) are widely distributed in the animal and plant worlds and have important biological significance. [10–416-6 ]

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
[37.] Rodriguez C, Hardy E (2015) Lipopolysaccharide aggregates in native agarose gels detected by reversible negative staining with imidazole and zinc salts.
An example of the elution profile with a solution containing 250 mmol l-1 imidazole (for details, see Materials and Methods) is shown in Figure 2B.
Peaks observed at 1500-1600 [cm.sup.-1] are due to the aromatic C=C and C=N stretching bands and they arise from in-plane bending of N-H and conjugation vibration between benzene and imidazole rings.
0.5M NaCl with 60 ppm and 100 ppm imidazole were used throughout this study.
The interaction of pure Imidazole with mesenchymal stem cell might provide new insights on the toxic potential of Imidazole in creating any stem cell related pathologies.
Light orange crystals, Yield (2.9 g, 90%), m.p 202-204[degrees]C, IR (KBr, [v.sub.max] in [cm.sup.-1]): 3401 (-NH), 2956 (=C-H), 1891 (C=N), 1610 (C=C), 1644 (C=O), [sup.1]H NMR (DMSO-[d.sub.6], 400 MHz) [delta] ppm: 7.33-7.37 (d, 1H, -C=CH, vinylic proton, [J.sub.H-H] = 16.4 Hz), 7.48-7.67 (m, 8 aryl, 5 phenyl), 10.2 (s, 1H, -NH of benzimidazole), [sup.13]C NMR (DMSO-[d.sub.6], 100 MHz) d ppm: 102, 106, 108, 110, 112, 120, 121, 122, 128, 129, 130, 132, 142, 148, 152, 190 (12 aryl carbons, 6 phenyl carbons, 2 vinylic carbons, 1 imidazole quaternarycarbon and 1 carbonyl carbon), MS (m/z): 325.2 ([M.sup.+*]), Anal.
The pellet was then washed twice in 4 mL imidazole buffer by centrifugation as stated earlier and resuspended with 3 mL imidazole buffer containing 1% bovine serum albumin (Sigma-Aldrich, USA).
Subsequently, Mannich bases (100 mmol) were dissolved in water (100 mL) and imidazole (200 mmol) was added.
An ionic liquid type imidazolium catalyst enhanced the conductivity of epoxyanhydride resin based electrical conductive adhesives (ECAs) by more than two orders of magnitude compared with common imidazole compounds.
Inhibition of cytochromes P450 by antifungal imidazole derivatives.
MoldWiz INT-1322 has been proven to have no impact on the cure kinetics of imidazole or amine accelerated DICY.