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Related to Imidazoles: clotrimazole, Triazoles


(organic chemistry)
C3H4N2 One of a group of organic heterocyclic compounds containing a five-membered diunsaturated ring with two nonadjacent nitrogen atoms as part of the ring; the particular compound imidazole is a member of the group.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



(glyoxaline, 1,3-diazole) a heterocyclic base. Colorless crystals; boiling point, 256°C. Imidazole is readily soluble i n water and alcohol and moderately soluble in ether. It is aromatic, that is, readily undergoes halogenation, nitration, and sulfonation. The hydrogen of the NH group can be replaced by alkyl by the action of, for example, dimethylsulfate. Imidazole is prepared by reacting glyoxalwith ammonia and formaldehyde. Its derivatives (histamin, histidine, carnosine, pilocarpine) are widely distributed in the animal and plant worlds and have important biological significance. [10–416-6 ]

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
However, despite showing high selectivity for fungal CYP450 enzymes compared to imidazoles, triazoles can still lead to adverse side reactions mostly by interfering with human CYP450 enzymes.
Highly efficient, four-component one-pot synthesis of tetrasubstituted imidazoles using Keggin-type heteropolyacids as green and reusable catalysts.
Wagh, "A review on "Drugs containing imidazoles and triazole heterocyclic ring in antifungal therapy"," International Journal of Pharmacy and Technology, vol.
In conclusion, Rochelle salt can catalyze the one-pot synthesis of a large number of multisubstituted imidazoles under microwave conditions very efficiently.
Complexes 2, 3, 4, and 5 were also synthesized in a similar fashion described above as 1 by employing Me-ImH(1.0 mmol, 0.07 g); Et-ImH (1.0 mmol 0.08 g); 2-benz-ImH(1.0 m mol, 0.12 g); benz-ImH (1.0 m mol; 0.13 g), respectively, in place of imidazole (ImH).
Jisova, "Curing mechanism of epoxides by imidazoles," Journal of Applied Polymer Science, vol.
Kantevari, "Tetrabutylammonium bromide (TBAB) in isopropanol: an efficient, novel, neutral and recyclable catalytic system for the synthesis of 2,4,5-trisubstituted imidazoles," Catalysis Communications, vol.
The imidazole antifungal agent clotrimazole has been widely used topically for the treatment of superficial dermatophytosis for a long time.4,5
[12] Drabu, S., Puratchikody, A., Munirajan, S., and Kumar N., 2006, "Synthesis and pharmacological activity of some 2-substituted 4, 5-diphenyl imidazoles," Indian J.
(1) The triple-drug regimen (a proton-pump inhibitor [PPI] and clarithromycin with amoxicillin, tinidazole, or another imidazole) is commonly used to treat H pylori in Europe and in the United States.
Vaginal candidiasis is commonly treated with a variety of agents including topical or oral imidazoles and triazoles; polyene macrolide compounds, such as nystatin; and boric acid.
The book contains over one hundred separate contributions covering chemistry such as naturally occurring phenolic compounds as inhibitors of free radical formations in the Maillard reaction and the formation of some Pyrido - (3, 4-d) - imidazoles by Maillard reaction, to food such as kinetics of the early Maillard reaction during heating of milk and simultaneous determination of protein-bound Maillard products by ion exchange chromotography and photodiode array detection to biochemistry such as the effect of glucose and glycation on protein oxidation and the influence and impact of nonenzymic browning reaction on proteins in milk and indigenous dairy products of India.