Imidazole

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Related to Imidazoles: clotrimazole, Triazoles

imidazole

[‚im·ə′da‚zōl]
(organic chemistry)
C3H4N2 One of a group of organic heterocyclic compounds containing a five-membered diunsaturated ring with two nonadjacent nitrogen atoms as part of the ring; the particular compound imidazole is a member of the group.

Imidazole

 

(glyoxaline, 1,3-diazole) a heterocyclic base. Colorless crystals; boiling point, 256°C. Imidazole is readily soluble i n water and alcohol and moderately soluble in ether. It is aromatic, that is, readily undergoes halogenation, nitration, and sulfonation. The hydrogen of the NH group can be replaced by alkyl by the action of, for example, dimethylsulfate. Imidazole is prepared by reacting glyoxalwith ammonia and formaldehyde. Its derivatives (histamin, histidine, carnosine, pilocarpine) are widely distributed in the animal and plant worlds and have important biological significance. [10–416-6 ]

References in periodicals archive ?
A pesar de que son bien tolerados, los imidazoles o los triazoles son compuestos mas eficaces contra la candidiasis vaginal.
Imidazole ring system is one of the most important substructures found both in a large number of natural products and synthetic drugs along with the wide spectrum of physiological activities displayed by these compounds.
The imidazole antifungal agent clotrimazole has been widely used topically for the treatment of superficial dermatophytosis for a long time.
Los imidazoles topicos y las alilaminas se pueden usar asociados, pues evitan la diseminacion y pueden acortar el tiempo en que el paciente es infectante.
Also offers a wide range of imidazole accelerators, including 2-methylimida-zole, 2-ethyl-4-methylimidazole, and 2-phenylimidazole, as well as several developmental types.
Imidazole and its derivatives are an important class of heterocyclic and many naturally occurring imidazoles are known to possess biological activity [5].
Within the group of the azole fungicides, currently 16 triazoles (bitertanol, cyproconazole, difenoconazole, epoxiconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, metconazole, myclobutanil, penconazole, propiconazole, tebuconazole, triadimefon, triadimenol, triticonazole) and three imidazoles (imazalil, prochloraz, and triflumizole) are listed.
Pyrrolo-[1, 2-a] imidazoles have been synthesized by diastereoselective of 1,3dipolar cycloaddition by using 4, 5-dihydroimidazolium ylides with an alkylating agent and base or more recently carbenoid insertion to dihydroimidazoles.
An RCT found less nausea, headache, and abdominal pain with intravaginal imidazoles, but more vulvar irritation and vaginal discharge than oral fluconazole.
He discussed the suitability of such hardeners as DICY, modified DICY with aromatics, aromatic amines (DDS), imidazoles, carboxyl functional polyesters, phenolic curing agents, Novalac hardeners, and anhydride hardeners.