With these "humanized" mouse models, the biologists then tested a variety of immune suppressing molecules alone or in combination and discovered one combination that worked perfectly to protect cells derived from human embryonic stem cells from immune rejection
However, once it is generally recognized that parthenogenetic cells have similar characteristics of embryonic stem cells and offer the potential to solve critical immune rejection
issues - while not requiring the destruction of viable human embryos - we expect these cells to be increasingly used in government funded research to study ways of reducing human suffering and treating intractable human diseases.
Mueller and the University of Wuerzburg have approved ISCO's human parthenogenetic stem cells for research is a strong validation of their value in creating therapeutic cells that have significant immune rejection
advantages and significant ethical advantages," said Kenneth Aldrich, ISCO's Chairman and CEO.
Being a person's own cells, they would avoid immune rejection
, he says.
However, George Daly, a Harvard stem-cell researcher, said the finding raises the possibility that someday expectant parents can freeze amniotic stem cells for future tissue replacement in a sick child without fear of immune rejection
In all other cases, such nuclear transfer clones contain mitochondrial DNA, derived from the cytoplasm of the ovum, that is foreign to the patient, and that would cause immune rejection
in patients if injected.
Drugs inducing beta cell regeneration may then be combined with therapies to block immune rejection
of the newly formed cells, thereby restoring normal function to the pancreas gland.
The most common argument in support of cloning for stem cell rearch is that it will solve the immune rejection
problem with stem cell transplantation because the patient will get back her own undifferentiated cells instead of transplanted stem cells from a stranger.
Therefore, we would not expect to see immune rejection
of the cells or antibodies produced against the proteins.
These hESC-derived hematopoietic cells not only have potential application in hematopoietic transplantation therapies, but also could be used to prevent immune rejection
of transplanted cells derived from hESCs, thereby potentially eliminating the need for immunosuppressive drugs or nuclear transfer technologies.
As a result, immune rejection
will always set a limit on the utility of these cells in medical practice.
Livestock may be modified so that their organs don't induce immune rejection
in humans and can therefore act as life-saving transplants.