light chain

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light chain

[′līt ′chān]
(immunology)
The smaller of the two types of chains found in immunoglobulin molecules, molecular weight 23,500. Also known as B chain; L chain.
References in periodicals archive ?
The results were as follows: Flow cytometric immunophenotyping identifies a phenotypically distinct population of cells with low light scatter properties that express CD19, low density CD20, CD5, and CD45 and display Kappa immunoglobulin light chain restriction.
Systemic AL amyloidosis (formerly primary amyloidosis) is a monoclonal plasma cell proliferative disorder in which monoclonal immunoglobulin light chains are deposited in tissues.
Using matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry to detect monoclonal immunoglobulin light chains in serum and urine.
It has been proposed that when the concentration of serum FLCs exceeds 500 mg/L and proteinuria is mainly composed of immunoglobulin light chains, it is extremely likely that the onset of AKI is due to myeloma kidney; in those cases, renal biopsy is usually unnecessary.
Increased concentrations of immunoglobulin light chains might be an indicator of B cell hyperactivity thereby reflecting disease activity better than other inflammation parameters when B cell involvement is suspected in the pathogenesis.
Kappa light chain-associated Fanconi's syndrome: molecular analysis of monoclonal immunoglobulin light chains from patients with and without intracellular crystals.
Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004.
a high degree of specificity, so they recognize immunoglobulin light chains when they are free but not when they are bound to heavy chains in intact immunoglobulin molecules; and
The kidney is one of the most common organs involved by amyloidosis, especially by AL amyloidosis, which contains immunoglobulin light chains produced by abnormal clonal plasma cells.
The amyloid deposits were composed of immunoglobulin light chains of the same types expressed by the neoplastic cells in all 3 cases.
Up to 80% of patients with LPL/WM will have monoclonal immunoglobulin light chains (Bence-Jones proteins) in the urine.
Immunofluorescence microscopy is usually helpful in delineating whether the amyloid is derived from the immunoglobulin light chains or heavy chains.

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