Zhang, "Plasma immunoproteasome
predicts early hemorrhagic transformation in acute ischemic stroke patients," Journal of Stroke and Cerebrovascular Diseases, vol.
deficiency alters retinal proteasome's response to stress," Journal of Neurochemistry, vol.
in antigen processing and other immunological functions.
MHCI presentation may be dependent upon the immunoproteasome
in murine macrophages, but not routine dendritic cells.
as a target in hematologic malignancies.
Laurent et al., "Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome
," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
(i-proteasome) is an isoform of the 20S proteasome.
In this pathway, the proteins that are destined for the presentation are marked by the ubiquitinylation and subjected to proteolytic cleavage by the immunoproteasome
. The fragments of peptides are transported to lumen of ER by the help of TAP (tAp1 and TAP2).
However, variable types of 20S complexes can associate with different regulatory particles, generating functionally distinct proteasomes such as the immunoproteasome
(Glickman and Ciechanover 2002; Kloetzel 2004).
Some subjects discussed are molecular chaperones in normal and pathologic states, genetic polymorphism of immunoproteasome
and its functional value, and genetic polymorphism of alpha-1-inhibitor of proteinases and its clinical value.
"Our strategy of evaluating KZR-616 in Phase 2 trials across multiple autoimmune indications is underway, building our case around the broad therapeutic potential of immunoproteasome