immunotoxin

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immunotoxin

[‚im·yə·nō′täk·sən]
(immunology)
Conjugate of antibody and toxic protein such that the specificity of the antibody molecule is combined with the cytotoxic property of the toxin.
References in periodicals archive ?
By fusing a cell-killing toxin to such an antibody, neuroscientists have created immunotoxins that seek out specific classes of nerve cells.
In 2004, the company decided to focus its therapeutic activities on oncology and in December of that year in-licensed two anti-CD22 immunotoxin programs from the National Cancer Institute (NCI) -- GCR-3888 and GCR-8015.
Like the immunotoxins, interleukin-2, a protein that stimulates the immune system's cells, causes vascular leaks at high doses.
We make the immunotoxin, do all the preclinical studies, file and get an IND (Investigational New Drug Application) with the FDA, and do the clinical study, all on-site.
While immunotoxins have entered the arsenal of anti-cancer drugs, there have been problems with their clinical use.
Under the existing collaborative agreement, the NCI will continue to evaluate our proprietary technology as applied to certain immunotoxins currently in development at the NCI," said Dr.
We will initially work with the NCI to enhance immunotoxins currently under study at the NCI," said Dr.
ONCONASE / antibody chemical conjugates can be as potent in killing tumor cells as those using plant and bacterial toxins, but are far less toxic to mice than classical immunotoxins.
Subsequently their team discovered some of the first monoclonal antibodies to antigens expressed by human tumors, and they were among the first to publish on the utility of such antigens as possible targets for antibody-mediated cancer therapy via drug conjugates, immunotoxins, or antibodies alone.
A leader in the field of bacterial toxins for nearly four decades, among the practical applications of his research have been the development of vaccines including whooping cough and the design of immunotoxins to destroy certain cancer cells.
The latter was identified by Vitetta's group several years ago in its ongoing efforts to produce safer immunotoxins containing the A chain.
Among these constructs are immunotoxins, immunocytokines and T-cell recruitment via CD3 targeting.