However, it should be mentioned that there have been tools developed to address the confounding effects of population structure across inbred strains
; a popular statistical method for QTL mapping for this population is Efficient Mixed-Model Association (EMMA), available as an R package (Kang et al.
The application of these methods to an inbred strain
should be evaluated.
Since the convulsions of the EL mouse were first observed and established as epilepsy, the inbred strain
has been kept, and data were obtained to elucidate the mechanism of epilepsy and abnormal plasticity.
Indeed, inbred strains
of animals are frequently used in laboratories for experiments where for reproducibility of conclusions, all the test animals should be as similar as possible.
(1) The number of repetitions of some microsatellites differs among individuals or inbred strains
and therefore can be used as a marker, allowing researchers to track how specific microsatellite sequences are inherited.
Jackson Laboratory reported that "Inbred strains
within this program effectively remain genetically unchanged for at least the period of the program (projected 25 years)" .
Many studies that might explain this difference have been conducted, comparing these strains and a large panel of recombinant inbred strains
derived from them for both biological and behavioral factors.
Using an inbred strain
that Little originally created, one known as C57BL, an international consortium of scientists has deciphered nearly the entire DNA sequence of the mouse.
To create a CSS, an entire chromosome of one inbred strain
is replaced with that of another strain.
This illustrates the arbitrary nature of using a single inbred strain
for exposure modeling.
Falls and colleagues (1997) found that a marked FPS response could be detected in the DBA/2J (D2) but not in the C57BL/6J (B6) inbred strain
. This finding was confirmed by McCaughran and colleagues (2000).
Scientists first found evidence for the H-Y antigen when they transplanted skin between members of a highly inbred strain
of laboratory mice.