For the Nature Genetics study, Pardo-Manuel de Villena's team, including first author James Crowley, PhD, assistant professor of genetics, selected three genetically diverse inbred strains
of mice that were descended from a subspecies that evolved on different continents.
Worried that they might be missing important human end points by relying on established inbred strains
in research, Threadgill and other scientists created the Complex Traits Consortium (CTC) with a mission, he says, "to reinvent the mouse model so that it would contain genetic variability on the scale of what exists in humans.
Recombinant inbred strains
: Sets of animal strains that all are derived from the same two parental inbred strains
and which each carry a specific combination of the parental genes; within each RI strain all animals are genetically identical.
Using inbred strains
of fruit flies in controlled environments, researchers can use whole genome data, which captures genetic changes at the nucleotide level, to better explain why strains exhibit variable traits.
Nadeau and colleagues allowed two inbred strains
of mice to eat as many of the mouse equivalent of double cheeseburgers as they wanted.
This mouse strain exhibits significant advantages over such inbred strains
as 129, C57BL/J, BALB/c, DBA and CBA in respect of environmental resistance, reproduction and breeding, etc.
2]) offspring of two genetically distinct parent inbred strains
dominance and epistasis [Falconer & Mackay 1996]) in outcrossed hybrids by comparing each of the 10 outbred strains to the mean of the two inbred strains
from which it was created.
Charles River, despite years of experience in maintaining inbred strains
, also struggled to reproduce transgenic strains for distribution.
The white-footed mouse serves as a natural reservoir for AP-ha, and laboratory studies have shown that numerous inbred strains
of mice (e.
Additionally, gynogenetic fish p rovide an alternative organism for immunological investigations, where research has predominantly involved highly inbred strains
Other items in the NIA "zoo" include inbred strains
of mice, rats raised for generations on low-calorie diets, skin cultures from victims of premature aging syndromes, and living cells from individuals with a family history of Alzheimer's disease.