"The major reason we've been using inbred strains
in the first place, despite many known disadvantages, is because we had this expectation that the data would be tighter.
Numerous flow-induced genes were revealed by this study, including a group of 8 genes that showed very strong flow induced expression conserved in both inbred strains
. A group of 9 genes showed very strong flow induced expression with major differences between an aneurysm prone inbred rats and the aneurysm resistant inbred rats.
The scientists started with an observation that has been recognized in the field for years: Two inbred strains
of mice harbor different levels of Salmonella in their guts after being infected with the pathogen.
Ayca Dogan highlighted genetic model BXD recombinant inbred strains
. Inbred lines identify individual genes.
In addition, inbred strains
performed differently on memory tasks, such as the Morris water maze and the contextual fear conditioning test .
In both male and female mouse sets, the whole genome gene expression profiles were all from a total of 85 strains, including 64 BXD strains, parental strain C57BL/6J, two reciprocal F1 hybrids (B6D2F1 and D2B6F1), and 18 other common inbred strains
. The spleen was profiled using the Affymetrix GeneChip Mouse Gene 1.0 ST array.
However, a tradeoff is a greater ability to detect chemical hazards that might otherwise be missed in a single inbred strain
. Inbred strains
are more stable, better defined, and have more extensive background pathology data in archives as compared with classical outbred stocks.
In order to fine map the metabolism disorder QTLs on Chr 1 and identify the candidate genes, we established a population of Chr 1 substitution mouse strains, in which C57BL6/J (B6) was the host strain, and one KM mouse, five inbred strains
, and twenty-four wild mice captured from various locations in China were selected as the Chr 1 donors .
Recombinant inbred strains
: Sets of animal strains that all are derived from the same two parental inbred strains
and which each carry a specific combination of the parental genes; within each RI strain all animals are genetically identical.
Indeed, inbred strains
of animals are frequently used in laboratories for experiments where for reproducibility of conclusions, all the test animals should be as similar as possible.
Nadeau and colleagues allowed two inbred strains
of mice to eat as many of the mouse equivalent of double cheeseburgers as they wanted.