are more stable, better defined, and have more extensive background pathology data in archives as compared with classical outbred stocks.
For the Nature Genetics study, Pardo-Manuel de Villena's team, including first author James Crowley, PhD, assistant professor of genetics, selected three genetically diverse inbred strains
of mice that were descended from a subspecies that evolved on different continents.
Recombinant inbred strains
: Sets of animal strains that all are derived from the same two parental inbred strains
and which each carry a specific combination of the parental genes; within each RI strain all animals are genetically identical.
Using inbred strains
of fruit flies in controlled environments, researchers can use whole genome data, which captures genetic changes at the nucleotide level, to better explain why strains exhibit variable traits.
Nadeau and colleagues allowed two inbred strains
of mice to eat as many of the mouse equivalent of double cheeseburgers as they wanted.
This mouse strain exhibits significant advantages over such inbred strains
as 129, C57BL/J, BALB/c, DBA and CBA in respect of environmental resistance, reproduction and breeding, etc.
(RHA-I and RLA-I), derived from the Swiss sublines have been maintained and bred, and periodically phenotyped for two-way avoidance at our laboratory since 1997 (Aguilar, Flint, Gray, Dawson, Driscoll, Gimenez-Llort, Escorihuela, Fernandez-Teruel, & Tobena, 2002; Aguilar, Gil, Fernandez-Teruel, & Tobena, 2004; Driscoll et al.
2]) offspring of two genetically distinct parent inbred strains
dominance and epistasis [Falconer & Mackay 1996]) in outcrossed hybrids by comparing each of the 10 outbred strains to the mean of the two inbred strains
from which it was created.
Charles River, despite years of experience in maintaining inbred strains
, also struggled to reproduce transgenic strains for distribution.
However, our attempts to generate inbred strains
through continuous selfing have never been successful (W.
The white-footed mouse serves as a natural reservoir for AP-ha, and laboratory studies have shown that numerous inbred strains
of mice (e.