Although no evidence of hepatocytic degeneration or necrosis was seen in the H&E-stained sections of liver from the other 4 animals in this group (MPX-5 to MPX-8), the immunostain for viral antigen highlighted rare inclusion bodies
in the hepatocytes of animals MPX-6 and MPX-7, which indicated a small amount of monkeypox virus replication in the liver.
In the liver, most of the larger inclusion bodies
stained strongly positive for viral antigen (Figure 1C); however, some of the smaller inclusion bodies
similar to adenoviral inclusion bodies
can be induced by other viruses, including polyomavirus, herpesvirus, and circovirus.
Mass purification of nucleopolyhedrosis virus inclusion bodies
in the K-Series centrifuge.
Histopathologic evaluation of the skin nodules revealed marked hyperplasia of the epidermis with ballooning degeneration of cells and numerous eosinophilic intracytoplasmic inclusion bodies
p62 is also found in inclusion bodies
containing polyubiquitinated protein aggregates which are present in several neurodegenerative diseases such as Parkinson, Alzheimer, and Huntington's diseases.
Histopathological examination showed splenic parenchyma with discrete, round to oval noncaseating granuloma composed of epithelioid histiocytosis, multinucleated giant cells (Figure 2a), and asteroid inclusion bodies
System design information sharing at national and international levels, and inclusion bodies
responsible for the fight against cyber threats, cyber-terrorism and cyber-crime in this system on the basis of existing or newly defined competencies (National Cyber ?
However, the rapid and high-yield protein production often leads to polypeptide misfolding and results in protein aggregation into inclusion bodies
, rendering the target protein biologically inactive.
Langerhans cells have cytoplasmic inclusion bodies
known as Birbeck granules; a definitive diagnosis requires electron microscopy of Birbeck granules or CD 1 antigenic determinants by immunohistochemistry.
Cell culture, cytological tests for the detection of cytoplasmic inclusion bodies
, direct immunofluorescence (DFA), enzyme-linked immunosorbent assay (ELISA), DNA hybridization techniques and polymerase chain reaction (PCR) are several laboratory methods which are used for the diagnosis of C.
Histology showed multinucleate squamous cells with ground-glass viral nuclear inclusion bodies
, indicative of HSV infection.