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Also known as 2,3-benzopyrrole.
C6H4-(CHNH)CH A decomposition product of tryptophan formed in the intestine during putrefaction and by certain cultures of bacteria.
(organic chemistry)
Carcinogenic, white to yellowish scales with unpleasant aroma; soluble in alcohol, ether, hot water, and fixed oils; melt at 52°C; used as a chemical reagent and in perfumery and medicine.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



(2, 3-benzopyrrole), colorless crystals with an unpleasant odor. Melting point, 52°C; boiling point, 254°C. It is soluble in hot water and organic solvents. Indole is present in coal tar, from which it is extracted as salts of alkali metals, as well as in certain essential oils (for example, oil of jasmine). Along with skatole (3-methyl-indole), it is found in the intestines of human beings and mammals.

Many indole derivatives, for example, 3-indoleacetic acid (heteroauxin A, a growth substance), serotonin, and reserpine, are biologically active. Indole is a raw material for synthesizing heteroauxin and tryptophane, and is used in the perfumery industry to improve and strengthen the scents of flower essences.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Perumal, "Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and Npropargyl di(indolyl)indolin-2-ones," Bioorganic & Medicinal Chemistry Letters, vol.
With the ratio of PWA/MCM-41 exceeding 60 wt%, the yields of the 3,3-di(indolyl)indolin-2-one decreased, because the MCM-41 pores might be blocked by the excessive amounts of PWA.
However, the amount of solvent obviously influenced the formation of the 3,3-di(indolyl)indolin-2-one and the best outcome was obtained with 0.3 mL THF at 0.1 mmol scale of isatin (Table 1, entry (18)).
However, product 3l, the yield of 5-methyl-3,3-di(indolyl) oxindole, was excellent (Table 2, entry (12)).
Finally, another indole reacted with (7) to provide the desired product 3,3-di(indolyl)indolin-2-one (3) and regenerate the catalyst for the next catalytic cycle (Scheme 3).
In a general way all the parameters obtained by DFT calculations show the necessity of having an electronrich aromatic bond to mimic the indolyl moiety in compound 1.
Also, DFT descriptors show that the presence of an electron-rich aromatic ring is necessary to mimic the indolyl moiety present in compound 1.
Keywords: bis(indolyl)methanes water environmentally friendly synthesis
Bis(indolyl)methanes and their analogs are present in terrestrial and marine organism [5].
Some Bis(indolyl)alkanes are used as PPARr agonists and in cancer chemotherapy [14].
For the bis(indolyl)methanes synthesis numerous methods have been reported i.e.
Perumal, "Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di(indolyl)indolin-2-ones," Bioorganic and Medicinal Chemistry Letters, vol.