Indoxyl


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indoxyl

[in′däk·səl]
(organic chemistry)
(C8H6N)OH A yellow crystalline glycoside, used as an intermediate in the manufacture of indigo.

Indoxyl

 

pale yellow crystals with an unpleasant odor; melting point, 85°C. The substance exists in two tautomeric forms:

Indoxyl is present in the urine of human beings and animals as the potassium salt of 3-indoxyl sulfuric acid (urinary indican) and in the juices of certain tropical plants (in the form of glycosides), from which it can be obtained by hydrolysis.

Indoxyl is an important intermediate product in the synthesis of indigo, a dye formed during the oxidation of indoxyl. Reduction of indoxyl yields indole.

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Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease.
Research Progress on the Relationship between Coronary Artery Calcification and Chronic Renal Failure
The production of p-cresol sulfate and indoxyl sulfate in vegetarians versus omnivores.
Functional Gastroenterology Bolus: Does It Start in the Gut? Relationships Between the GI Tract and Chronic Kidney Disease
Indolecarboxylic acid ester [right arrow] Indoxyl + Acid.
Study of urinary protein and leucocytes in normotensive and hypertensive children and adults
Enzymaticdegradation of urinary indoxyl sulfate by Providencia stuartii and Klebsiella pneumoniae causes the purple urine bag syndrome.
The case of the purple urinary collection Bag
Key Words: Nephrostomy tube, purple urine, PUBS, long-term indwelling catheter, alkaline urine, indoxyl sulfate, L-Tryptophan.
Monolateral purple urine bag syndrome in a patient with bilateral nephrostomy tubes
Indole was absorbed into the portal circulation and conjugates with SO [sub]4 to form indoxyl sulfate.
Analysis of risk factors in elderly patients with purple urine bag syndrome: A retrospective analysis in a medical center in northern Taiwan
In presence of a sulphatase producing organism, the urinary bacteria break down the indoxyl sulphate to indoxyl via sulphatase enzyme.
Purple urine bag syndrome: a case report
Renal medicine, pathophysiology, nephrology, and other researchers from Europe, the US, and Japan cover the definition, classification, listing, and mass spectrometric analysis of uremic toxins; selected toxins, including indoxyl sulfate, asymmetric dimethylarginine, parathyroid hormone, and advanced glycation endproducts, and their chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods; and the therapeutic removal of toxins through hemodialysis, peritoneal dialysis, and oral sorbents.
Uremic toxins
Alleviation of cisplatin-induced acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats.
Quercetin: broad-spectrum protection
Urinary tract infection (uti) with bacteria possessing indoxyl phosphatase and sulphatase enzymes, commonhyprovidencia stuarttiand rettgeri, pseudomonas auruginosa, proteus mirabilis, escherichia coli, klebsiella pneumoniae,morganella, citrobacter species, group b streptococci and enterococci (8, 13).
Medicine in pictures: purple urine bag syndrome
La reaccion en cadena responsable para el PUBS comienza con el triptofano de los alimentos que es metabolizado a indol en el intestino, luego es absorbido, pasa a la circulacion portal y convertido a sulfato de indoxyl en el higado y excretado en la orina.
Sindrome de la bolsa de orina purpura
Some HPLC peaks were identified, such as creatinine, uric acid (the highest contribution), hypoxanthine, indoxyl sulphate and hippuric acid.
Behaviour of uremic toxins and UV absorbance in respect to low and high flux dialyzers/Ureemiliste toksiinide ja nende UV-sorptsiooni uurimine vedeliku madala ning korge labilaskevoimega dialusaatorite korral

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