Indoxyl


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indoxyl

[in′däk·səl]
(organic chemistry)
(C8H6N)OH A yellow crystalline glycoside, used as an intermediate in the manufacture of indigo.

Indoxyl

 

pale yellow crystals with an unpleasant odor; melting point, 85°C. The substance exists in two tautomeric forms:

Indoxyl is present in the urine of human beings and animals as the potassium salt of 3-indoxyl sulfuric acid (urinary indican) and in the juices of certain tropical plants (in the form of glycosides), from which it can be obtained by hydrolysis.

Indoxyl is an important intermediate product in the synthesis of indigo, a dye formed during the oxidation of indoxyl. Reduction of indoxyl yields indole.

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Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease.
The production of p-cresol sulfate and indoxyl sulfate in vegetarians versus omnivores.
Enzymaticdegradation of urinary indoxyl sulfate by Providencia stuartii and Klebsiella pneumoniae causes the purple urine bag syndrome.
Key Words: Nephrostomy tube, purple urine, PUBS, long-term indwelling catheter, alkaline urine, indoxyl sulfate, L-Tryptophan.
Indole was absorbed into the portal circulation and conjugates with SO [sub]4 to form indoxyl sulfate.
In presence of a sulphatase producing organism, the urinary bacteria break down the indoxyl sulphate to indoxyl via sulphatase enzyme.
Renal medicine, pathophysiology, nephrology, and other researchers from Europe, the US, and Japan cover the definition, classification, listing, and mass spectrometric analysis of uremic toxins; selected toxins, including indoxyl sulfate, asymmetric dimethylarginine, parathyroid hormone, and advanced glycation endproducts, and their chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods; and the therapeutic removal of toxins through hemodialysis, peritoneal dialysis, and oral sorbents.
Alleviation of cisplatin-induced acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats.
Urinary tract infection (uti) with bacteria possessing indoxyl phosphatase and sulphatase enzymes, commonhyprovidencia stuarttiand rettgeri, pseudomonas auruginosa, proteus mirabilis, escherichia coli, klebsiella pneumoniae,morganella, citrobacter species, group b streptococci and enterococci (8, 13).
La reaccion en cadena responsable para el PUBS comienza con el triptofano de los alimentos que es metabolizado a indol en el intestino, luego es absorbido, pasa a la circulacion portal y convertido a sulfato de indoxyl en el higado y excretado en la orina.
Some HPLC peaks were identified, such as creatinine, uric acid (the highest contribution), hypoxanthine, indoxyl sulphate and hippuric acid.