Indoxyl


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indoxyl

[in′däk·səl]
(organic chemistry)
(C8H6N)OH A yellow crystalline glycoside, used as an intermediate in the manufacture of indigo.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Indoxyl

 

pale yellow crystals with an unpleasant odor; melting point, 85°C. The substance exists in two tautomeric forms:

Indoxyl is present in the urine of human beings and animals as the potassium salt of 3-indoxyl sulfuric acid (urinary indican) and in the juices of certain tropical plants (in the form of glycosides), from which it can be obtained by hydrolysis.

Indoxyl is an important intermediate product in the synthesis of indigo, a dye formed during the oxidation of indoxyl. Reduction of indoxyl yields indole.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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Interestingly, in this analysis indoxyl sulfate was clustered with the group of strong AhR agonists (Cluster 2).
The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity
These changes in buffering components are quite interesting to say the least, although they are yet an underestimated possibility in improving the inadequate indoxyl sulfate elimination during renal replacement therapy.
Indoxyl Sulfate Elimination in Renal Replacement Therapy: Influence of Citrate- versus Acetate-Buffering Component during Bicarbonate Dialysis
Microbial diversity is significantly damaged in CKD patients, with a decreased number of beneficial bacteria that generate SCFAs and an increase in bacteria that produce uremic toxins (indoxyl sulfate, p-cresyl sulfate, and TMAO) [52].
Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome
Indolecarboxylic acid ester [right arrow] Indoxyl + Acid.
Study of urinary protein and leucocytes in normotensive and hypertensive children and adults
Meyer, "The production of p-Cresol sulfate and indoxyl sulfate in vegetarians versus omnivores," Clinical Journal of the American Society of Nephrology, vol.
A Metabolomics-Based Strategy for the Mechanism Exploration of Traditional Chinese Medicine: Descurainia sophia Seeds Extract and Fractions as a Case Study
Nevertheless, other familiar metabolites reported such as indoxyl, oxindole, anthranilate, salicylate and gentisic acid, and hydroxyindole in similar researches were not observed [14].
Analysis of the Metabolites of Indole Degraded by an Isolated Acinetobacter pittii LI
Pan et al., "Indoxyl sulfate predicts cardiovascular disease and renal function deterioration in advanced chronic kidney disease," Archives of Medical Research, vol.
Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate Levels
Tyrosine can be fermented in the large intestine, resulting in the microbial formation of p-cresol and indoxyl (a phenolic compound), which after hepatic sulfation become p-cresyl sulfate and phenol sulfate [24, 45].
Metabolic Differences between Dogs of Different Body Sizes
These metabolites mainly are amino acids, hydroxyl acids, fatty acids, carbohydrates, and several indole-containing metabolites such as indoxyl sulfate, 3-indolepropionic acid, and serotonin.
Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment
Upon obtaining the colonies, the biochemical tests including catalase, Indoxyl acetate hydrolysis were used and in order to differentiate between the two species Jejuni and Coli hippurate hydrolysis test was conducted, which was positive for Jejuni (1).
Detection of campylobacter species in poultry meat and edible offal's in Western Azerbaijan province
However in our laboratory setup, histochemical staining for enzymes such as alkaline phosphatase, phosphorylase, succinic dehydrogenase, indoxyl esterase, and acid phosphatase was not available; they were not performed.
Histopathological study of 26 rare skin adnexal tumours over 5 years--a diagnostic dilemma!

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