Enzyme Inhibitor

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Enzyme Inhibitor

 

a chemical substance that selectively inhibits the activity of an enzyme or a group of related enzymes. Even in very low concentrations, enzyme inhibitors repress an organism’s vital physiological functions. Many toxic substances, including pesticides, such nerve gases as lewisite, and such respiratory toxins as cyanides and hydrogen sulfide, have a toxic effect owing to the inhibition of enzymes, for example, the enzyme cholinesterase in arthropods.

The study of the effect of enzyme inhibitors on enzymes or groups of enzymes facilitates the search for antidotes or for new pesticides to control harmful insects, mites and ticks, and weeds. The term “enzyme inhibitors” sometimes refers to enzymes in the poisons of snakes, bees, and scorpions that destroy tissues or blood cells in man and animals.

References in periodicals archive ?
To determine the kinetics parameters, Dixon plot was used to determine inhibition constant (Ki) [15] and Lineweaver-Burk plot [16] over the substrate was used at different concentrations 2.
The patterns of inhibition and the inhibition constants are presented in Table-3.
Graphical inspection from different plots was used to illustrate the inhibition constants ([K.
Binding to CB2 was weaker with inhibition constants exceeding 50[micro]M for EGC and ECG.
02 mg/ml (a) The apparent inhibition constant (Ki) of test compounds was calculated using Lineweaver-Burk plots.
THE I50 INHIBITION CONSTANTS OF FIVE XENOBIOTIC COMPOUNDS ON THE CRUDE GSTS FROM DIFFERENT DEVELOPMENTAL STAGES OF BACTROCERA MINAX.
The dissociation constants determined from these experiments were similar to the inhibition constants.
6 In previous projects, after a list of computational "hits" has actually been screened in biological assays to determine inhibition constants, the percentage of compounds meeting a pre-established level of antagonistic activity in vitro has ranged between 5 and 20%.
Inhibition constants were derived from the study and discussed in relation to the propensity of the active constituents concerned to cause drug-herb interaction.