1C) suggesting that the inhibition of COX-2
protein was the result of increased transcription.
While specific inhibition of COX-2
with celecoxib alone was sufficient to cause increased utilization of arachidonate by the lipoxygenase pathway, increases of LTB4 production were even greater in the presence of indomethacin, suggesting that the inhibition of both COX-1 and COX-2 provided more arachidonate substrate for metabolism by the lipoxygenase pathway.
These newly recognized effects seem to result from activities beyond the drugs' inhibition of COX-2
The purported benefit of selective inhibition of COX-2
is effective anti-inflammatory activity with decreased gastric and duodenal ulceration and bleeding for patients with osteoarthritis and rheumatoid arthritis.
More importantly, inhibition of COX-2
activity using the COX-2 selective inhibitor, NS398 results in a dose-dependent attenuation of A[beta]-induced cell death (Fig.
The selective inhibition of COX-2
by MK-966 offers the potential to produce significant analgesic and anti-inflammatory benefits with fewer gastrointestinal side effects.
Both genetic and pharmacological inhibition of COX-2
could enhance the ability of DSS inhibiting A549 cells growth.
For balanced selective inhibition of COX-2
, combined with the inhibition of TNF-alpha and IL-1 beta, to work, it is essential to block the additional inflammatory pathway, 5-lipoxygenase (5-LOX), which produces pro-inflammatory leukotrienes.
The inhibitory effects of gammaT and gamma-CEHC stemmed from their inhibition of COX-2
activity, rather than affecting protein expression or substrate availability, and appeared to be independent of antioxidant activity.
49-55) However, although COX-2 is upregulated in inflammation, its activity is also upregulated in healing damaged tissue; thus, inhibition of COX-2
activity may delay healing in certain circumstances.
It is now recognized that the antiinflammatory and analgesic actions of nonsteroidal antiinflammatory drugs are largely attributable to inhibition of COX-2
Some researchers suggest that aspirin's inhibition of Cox-2
may explain why it seems to defend against colon cancer.