cox-2 inhibitor

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cox-2 inhibitor:

see nonsteroidal anti-inflammatory drugnonsteroidal anti-inflammatory drug,
a drug that suppresses inflammation in a manner similar to steroids, but without the side effects of steroids; commonly referred to by the acronym NSAID .
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References in periodicals archive ?
In light of the fact that the inhibition of COX-2 suppresses both pro- and anti-tumorigenic PGs, an mPGES-1-specific inhibitor that blunts protumorigenic [PGE.
Anti-inflammatory compounds function through inhibition of COX-2 is applied [26].
Inhibition of COX-2 by celecoxib resulted in significant effects (defined as changes of 50%) on various transcripts.
COX-2 overexpression is associated with more aggressive biological tumor behaviors (Liao and Milas 2004), and the inhibition of COX-2 has been regarded as an effective anticancer strategy (Davies et al.
In addition, suppression of muscle pain by using non-steroidal anti-inflammatory drugs, with the resulting decrease in prostaglandins release and inhibition of COX-2, can impair healing of the lesion and delay the hypertrophic adaptation of the muscle after strength training [7].
25,26) Thus, the therapeutic effects of conventional NSAIDs are derived from inhibition of COX-2, while the adverse effects of these agents, particularly in the upper GI tract, arise from inhibition of COX-1 activity.
In the current report, the researchers surveyed a series of different types of NSAIDs for inhibition of COX-2.
Further, activation of PPAR-[gamma] by cigiltazone (PPAR-[gamma] ligand) decreases the COX-2 expression (23), and the inhibition of COX-2 induces PPAR-[gamma] expression (24).
23) Since the beneficial anti-inflammatory and analgesic effects occur through the inhibition of cox-2, drugs that would inhibit cox-2 while sparing cox-1 have been developed.
Inhibition of COX-2 produces anti-inflammatory, analgesic and antipyretic effects, while inhibition of COX-1 appears to be responsible for the adverse effects of NSAIDs.
8) The inhibition of COX-2 is the primary mechanism by which the nonselective NSAIDs provide analgesia (8); the simultaneous inhibition of COX-1 is the primary mechanism responsible for the GI side effects associated with NSAID use.

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