inhibitory postsynaptic potential

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inhibitory postsynaptic potential

[in′hib·ə·tȯr·ē pōst·sə′nap·tik pə′ten·chəl]
(neuroscience)
A transient, graded hyperpolarization of the postsynaptic membrane, mediated by a chemical neurotransmitter, in response to action potentials arriving at the endings of the presynaptic neurons.
References in periodicals archive ?
In postsynaptic buccal cells, B34 and B40 produce chloride-mediated rapid inhibitory postsynaptic potentials (IPSPs) that are desensitized by GABA and the [GABA.sub.A] agonist muscimol, blocked by the [GABA.sub.A] antagonists picrotoxin and bicuculline, and augmented by the GABA uptake inhibitor nipecotic acid (Jing et al., 2003).
It is physiologically controlled by excitatory presynaptic potentials of Ia afferent fibers and inhibitory postsynaptic potentials from muscle spindles of antagonistic muscles.
with [E.sub.i] = [E.sub.i](t), t [greater than or equal to] 0 and [I.sub.j] = [I.sub.j](t), t [greater than or equal to] 0 as Poisson processes with rates [[lambda].sub.E,i](t) and [[lambda].sub.I,j](t), a > 0 and b > 0 being the magnitude of each excitatory postsynaptic potential (EPSP) and inhibitory postsynaptic potential (IPSP); a cell receives excitatory postsynaptic potentials (EPSPs) at p synapses and inhibitory postsynaptic potentials (IPSPs) at q inhibitory synapses.
Fast inhibitory postsynaptic potentials (IPS[P.sub.s]) are mediated by [GABA.sub.A] receptors.