Therefore, it is important to study the delicate control mechanisms which exist in neurons to regulate the function of excitatory and inhibitory synapses
. Little is known about the ways in which these mechanisms shape the synaptic properties and the output of dentate granule cells.
In this paper, we introduced a physiologically realistic model to explain how the calcium signals can be modulated in the presence of inhibitory synapses
. Recently it has been observed that active GABAergic synapses not only strongly effect the calcium signals but also have the ability to completely change the intracellular calcium dynamics in dendritic spines, see for instance [4,5].
(2012) Elimination of inhibitory synapses
is a major component of adult ocular dominance plasticity.
Luo et al., "The specific [alpha]-neurexin interactor calsyntenin-3 promotes excitatory and inhibitory synapse
development," Neuron, vol.
In Goettingen, he learned patch clamping and [Ca.sup.2+] imaging from neurons in brain slices, and discovered long-term potentiation of inhibitory synapse
in the cerebellum.
In contrast, NL2 is located exclusively at inhibitory synapses
and clusters with [GABA.sub.A] and glycine receptors [220, 221].
The expression of neuroligins 1 and 2 in the CNS is restricted to excitatory and inhibitory synapses
Hauser et al., "Activity-dependent regulation of inhibitory synapse
development by Npas4," Nature, vol.
Age-dependent remodelling of inhibitory synapses
onto hippocampal CA1 oriens-lacunosum moleculare interneurons.
Epilepsy is a manifestation of abnormal electrical activity in the central nervous system, caused by the imbalance of excitatory and inhibitory synapses
Asmall proportion of spinal cord networks, but not frontal cortex networks, showed a transient increase in spike and burst activity with exposure to BoNT-A, an effect likely due to preferential inhibition of inhibitory synapses
expressed in this tissue.
The study found that transplanted iPSCs initially formed neurons producing GABA, the chief inhibitory neurotransmitter in the mammalian central nervous system, which plays a critical role in regulating neuronal excitability and acts at inhibitory synapses
in the brain.