DAPI: 4',6-diamidino- 2-phenylindole; IHC: inner hair cell
; P: postnatal day.
Pax2 expression was maintained in hair cells at P0, but the expression was notably weaker in the inner hair cells
in the basal region of the cochlea (Figure 6, A1-A4).
"Now we have found a new role for harmonin at the opposite end of these sound-sensing inner hair cells where it appears to control the signal output of the cell," added Lee.
Lee and colleagues, including UI postdoctoral fellows Frederick Gregory, Ph.D., and Keith Bryan, Ph.D., found that harmonin is important for regulating the number of calcium channels present at the sound-transmitting synapse of inner hair cells.
Staecker et al reported (1) that direct infusion of either neurotrophin-3 or BDNF into the scala tympani of a guinea pig cochlea after a loss of auditory hair cells compensates for the loss of trophic support (i.e., the inner hair cells
), (2) that the infused neurotrophin protects the auditory neurons of the spiral ganglion from cell death induced by neurotrophin molecule withdrawal, and (3) that either BDNF or neurotrophin-3 stimulated neuritic overgrowth of the VIIIth cranial nerve peripheral processes.
(d) The stereocilia of inner hair cells
become sharp in Myo3a mutant mice at the age of 2 months, 6 months, and 12 months.
Shang, "Effect of different gentamicin dose on the plasticity of the ribbon synapses in cochlear inner hair cells
of C57BL/6J mice," Molecular Neurobiology, vol.
IHC: inner hair cell
; OHCs: outer hair cells; PCs: inner and outer pillar cells; IPhC: inner phalangeal cell; DCs: Deiters' cells; IBC: inner border cell; Hen: Hensen's cell; GER: greater epithelial ridge; LER: lesser epithelial ridge.
Dallos, "Isolation of cochlear inner hair cells
," Hearing Research, vol.
Ad- GFP-Baylor transduces supporting cells (SCs) and inner hair cells
(IHCs) at basal (a), SCs at middle (b), and outer hair cells (OHCs) at apical turns (c).
In cultured cochlear explants, aminoglycoside incubation results in ERK1/2 activation in supporting cells, which promotes the death of surrounding inner hair cell