Inosine


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Related to Inosine: inosine pranobex

inosine

[′in·ə‚sēn]
(biochemistry)
C10H12N4O5 A compound occurring in muscle; a hydrolysis product of inosinic acid.

Inosine

 

(hypoxanthine riboside), a nucleoside consisting of the nitride purine base hypoxanthine and the carbohydrate ribose. Inosine is the intermediate product of nucleic acid metabolism. It is formed in the organism during the deamination of adenosine and also by synthesis from a free base according to the reaction hypoxanthine + ribose- 1 -phosphate ⇆ inosine + phosphate. This reversible reaction is catalyzed by the enzyme nucleoside phosphorylase.

References in periodicals archive ?
The compounds including Gly, urea, betaine, glutathione, and reduced form of nicotinamide adenine dinucleotide (NADH) showed positive loading scores, while compounds such as GMP, uric acid, spermine, uridine monophosphate (UMP), IMP, adenosine monophosphate (AMP), and inosine diphosphate showed negative loading scores for PC2(Table 2).
As part of the test, the team compared 8-oxo-inosine's abilities against a control, inosine. Unlike its 8-oxo counterpart, inosine enabled RNA to replicate with high speed and few errors.
ADA assays, in which ADA irreversibly catalyzes the conversion of adenosine into inosine, with hydrogen peroxide produced in the final enzymatic reaction, were performed using a commercial kit.
Analysis of correlation matrix showed high correlation of BCAAs and cysteine, PPP metabolites (except ribose 5-phosphate), and inosine and its metabolites (hypoxanthine and xanthine).
CDDP LuDing tablets 3 2008 [14] + vitamin C Liu and Hao CDDP LuDing tablets 3 2011 [15] + vitamin C + inosine tablets Meng et al.
Bruskov, "Guanosine and inosine display antioxidant activity, protect DNA in vitro from oxidative damage induced by reactive oxygen species, and serve as radioprotectors in mice," Radiation Research, vol.
Guanosine and inosine as natural geneprotectors for mice blood cells exposed to X-rays.
It was performed using primer pair used in previously described study [10] REP1 5'IIIGCGCCGICATCAGGC-32 and REP2 5'ACGTCTTATCAGGCCTAC-32, the primer REP1 has the nucleotide (I) inosine at ambiguous positions in the REP consensus sequence.
Merimepodib is an oral inhibitor of the enzyme inosine monophosphate dehydrogenase (IMPDH) with broad-spectrum antiviral properties.
The acquisition covers lomibuvir (VX-222), a non-nucleoside inhibitor of the HCV NS5B polymerase and merimepodib (VX-497), an inhibitor of inosine monosphosphate dehydrogenase with broad-spectrum antiviral properties.